Bone Marrow Ts65Dn Trisomy-Induced Changes in Platelet Functionality and Lymphocytopenia Do Not Impact Atherosclerosis Susceptibility in Mice

Bone Marrow Ts65Dn Trisomy-Induced Changes in Platelet Functionality and Lymphocytopenia Do Not Impact Atherosclerosis Susceptibility in Mice

The genetic disorder Down syndrome is associated with a decreased susceptibility for atherosclerotic cardiovascular disease. Hematological and immune abnormalities occur frequently in Down syndrome patients. We evaluated, in a preclinical setting, the impact of a Down syndrome-like hematological/imm...

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Bibliographic Details
Main Authors:	Suzanne J. A. Korporaal, Ronald J. van der Sluis, Miranda Van Eck, Menno Hoekstra
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Journal of Cardiovascular Development and Disease
Subjects:	bone marrow down syndrome mouse model lymphocytes monocytes macrophages
Online Access:	https://www.mdpi.com/2308-3425/8/9/110

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