Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs
Objectves: To comparatively explore the differences between 18 F-Flurpiridaz and 13 N-NH 3 ·H 2 O PET/CT myocardial perfusion imaging in miniature pigs. Methods: Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2020-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012120947506 |
| _version_ | 1797283592710127616 |
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| author | Jiao Wang MD Shuai Li Mpharm Tian-wen Liu BS Jie-min Zhang MD, PhD Yue Chen MD Jian-ming Li MD, PhD Wen-gui Xu MD, PhD |
| author_facet | Jiao Wang MD Shuai Li Mpharm Tian-wen Liu BS Jie-min Zhang MD, PhD Yue Chen MD Jian-ming Li MD, PhD Wen-gui Xu MD, PhD |
| author_sort | Jiao Wang MD |
| collection | DOAJ |
| description | Objectves: To comparatively explore the differences between 18 F-Flurpiridaz and 13 N-NH 3 ·H 2 O PET/CT myocardial perfusion imaging in miniature pigs. Methods: Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium to main organs with time were calculated and the best imaging time was confirmed for 18 F-Flurpiridaz imaging in normal group. The image quality score, summed rest score(SRS), Extend, total perfusion deficit(TPD) and left ventricle ejection fraction(LVEF) were respectively compared for 18 F-Flurpiridaz and 13 N-NH 3 ·H 2 O in infarction group. Results: 18 F-Flurpiridaz was rapid distributed in myocardium, and the background counts of cardiac cavity were very low, and no obvious interference extracardiac radioactivity was observed. The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13 N-NH 3 ·H 2 O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF. Conclusion: The results preliminaryly show that 18 F-FIurpiridaz is a promising positron MPI agent with good image quality, ability of accurately evaluating cardiac function, and also convenience for application. |
| first_indexed | 2024-03-07T17:32:58Z |
| format | Article |
| id | doaj.art-4a418d7c097a46f598c825ad4f58130f |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T17:32:58Z |
| publishDate | 2020-08-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-4a418d7c097a46f598c825ad4f58130f2024-03-02T17:18:56ZengSAGE PublicationsMolecular Imaging1536-01212020-08-011910.1177/1536012120947506Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature PigsJiao Wang MD0Shuai Li Mpharm1Tian-wen Liu BS2Jie-min Zhang MD, PhD3Yue Chen MD4Jian-ming Li MD, PhD5Wen-gui Xu MD, PhD6 Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Experimental Animal Center, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Experimental Animal Center, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, ChinaObjectves: To comparatively explore the differences between 18 F-Flurpiridaz and 13 N-NH 3 ·H 2 O PET/CT myocardial perfusion imaging in miniature pigs. Methods: Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium to main organs with time were calculated and the best imaging time was confirmed for 18 F-Flurpiridaz imaging in normal group. The image quality score, summed rest score(SRS), Extend, total perfusion deficit(TPD) and left ventricle ejection fraction(LVEF) were respectively compared for 18 F-Flurpiridaz and 13 N-NH 3 ·H 2 O in infarction group. Results: 18 F-Flurpiridaz was rapid distributed in myocardium, and the background counts of cardiac cavity were very low, and no obvious interference extracardiac radioactivity was observed. The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13 N-NH 3 ·H 2 O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF. Conclusion: The results preliminaryly show that 18 F-FIurpiridaz is a promising positron MPI agent with good image quality, ability of accurately evaluating cardiac function, and also convenience for application.https://doi.org/10.1177/1536012120947506 |
| spellingShingle | Jiao Wang MD Shuai Li Mpharm Tian-wen Liu BS Jie-min Zhang MD, PhD Yue Chen MD Jian-ming Li MD, PhD Wen-gui Xu MD, PhD Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs Molecular Imaging |
| title | Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs |
| title_full | Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs |
| title_fullStr | Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs |
| title_full_unstemmed | Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs |
| title_short | Preliminary and Comparative Experiment Study Between F-Flurpiridaz and N-NHHO Myocardial Perfusion Imaging With PET/CT in Miniature Pigs |
| title_sort | preliminary and comparative experiment study between f flurpiridaz and n nhho myocardial perfusion imaging with pet ct in miniature pigs |
| url | https://doi.org/10.1177/1536012120947506 |
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