Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy
Hepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome, diabetes, obesity, and nonalcoholic steatohepatit...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3710 |
| _version_ | 1797620459016028160 |
|---|---|
| author | Davide Gnocchi Carlo Sabbà Mara Massimi Antonio Mazzocca |
| author_facet | Davide Gnocchi Carlo Sabbà Mara Massimi Antonio Mazzocca |
| author_sort | Davide Gnocchi |
| collection | DOAJ |
| description | Hepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome, diabetes, obesity, and nonalcoholic steatohepatitis (NASH). The current protein kinase inhibitor therapies in HCC are very aggressive and not curative. From this perspective, a shift in strategy toward metabolic therapies may represent a promising option. Here, we review current knowledge on metabolic dysregulation in HCC and therapeutic approaches targeting metabolic pathways. We also propose a multi-target metabolic approach as a possible new option in HCC pharmacology. |
| first_indexed | 2024-03-11T08:41:43Z |
| format | Article |
| id | doaj.art-4a42078a5b81401e9a1c94abbea0de00 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:43Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4a42078a5b81401e9a1c94abbea0de002023-11-16T21:03:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244371010.3390/ijms24043710Metabolism as a New Avenue for Hepatocellular Carcinoma TherapyDavide Gnocchi0Carlo Sabbà1Mara Massimi2Antonio Mazzocca3Interdisciplinary Department of Medicine, School of Medicine, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyInterdisciplinary Department of Medicine, School of Medicine, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyInterdisciplinary Department of Medicine, School of Medicine, University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyHepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome, diabetes, obesity, and nonalcoholic steatohepatitis (NASH). The current protein kinase inhibitor therapies in HCC are very aggressive and not curative. From this perspective, a shift in strategy toward metabolic therapies may represent a promising option. Here, we review current knowledge on metabolic dysregulation in HCC and therapeutic approaches targeting metabolic pathways. We also propose a multi-target metabolic approach as a possible new option in HCC pharmacology.https://www.mdpi.com/1422-0067/24/4/3710hepatocellular carcinoma (HCC)metabolismtherapeutic approachesmultitarget metabolic systems |
| spellingShingle | Davide Gnocchi Carlo Sabbà Mara Massimi Antonio Mazzocca Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy International Journal of Molecular Sciences hepatocellular carcinoma (HCC) metabolism therapeutic approaches multitarget metabolic systems |
| title | Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy |
| title_full | Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy |
| title_fullStr | Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy |
| title_full_unstemmed | Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy |
| title_short | Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy |
| title_sort | metabolism as a new avenue for hepatocellular carcinoma therapy |
| topic | hepatocellular carcinoma (HCC) metabolism therapeutic approaches multitarget metabolic systems |
| url | https://www.mdpi.com/1422-0067/24/4/3710 |
| work_keys_str_mv | AT davidegnocchi metabolismasanewavenueforhepatocellularcarcinomatherapy AT carlosabba metabolismasanewavenueforhepatocellularcarcinomatherapy AT maramassimi metabolismasanewavenueforhepatocellularcarcinomatherapy AT antoniomazzocca metabolismasanewavenueforhepatocellularcarcinomatherapy |