The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016
Abstract Background This study aimed to investigate the relationship between serum testosterone levels and the risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link between serum testosterone and cardiovascular health, but the findings have been inco...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-023-01171-w |
| _version_ | 1797362769607000064 |
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| author | Xiangpeng Zhan Yang Liu Tao Chen Hao Wan Situ Xiong Sheng Li Xinxi Deng Luyao Chen Bin Fu |
| author_facet | Xiangpeng Zhan Yang Liu Tao Chen Hao Wan Situ Xiong Sheng Li Xinxi Deng Luyao Chen Bin Fu |
| author_sort | Xiangpeng Zhan |
| collection | DOAJ |
| description | Abstract Background This study aimed to investigate the relationship between serum testosterone levels and the risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link between serum testosterone and cardiovascular health, but the findings have been inconclusive. Methods This study was cross-sectional, and the data were obtained from the 2011–2016 cycle of the National Health and Nutrition Examination Survey (NHANES), which included a sample of 6,841 male participants. Serum testosterone levels were measured using a standardized assay, and CHF status was assessed through self-reporting. Covariates such as age, ethnicity, lifestyle factors, and health conditions were considered in the analysis. Results Among the participants, 242 individuals had a documented history of CHF. We observed a linear correlation between serum testosterone levels and CHF occurrence, with higher serum testosterone levels associated with a decreased risk of CHF (Q4 vs. Q1, OR = 0.29, 95% CI: 0.19–0.47, P < 0.001). After adjusting for confounding variables, multivariate analysis revealed that high serum testosterone levels remained significantly associated with a lower risk of CHF (OR: 0.47, 95% CI: 0.27–0.80, P = 0.01). Subgroup analysis indicated a significant association between high serum testosterone levels and reduced CHF risk in individuals over 50 years old. Conclusion Our findings suggest that the serum testosterone level was positively associated with CHF in adult males. This study highlights the potential role of serum testosterone in cardiovascular health, particularly in older individuals. Further research is needed to elucidate the underlying mechanisms and explore the clinical implications of these findings. |
| first_indexed | 2024-03-08T16:11:16Z |
| format | Article |
| id | doaj.art-4a44020d4dfe4da492036d824b80bc0e |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-08T16:11:16Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
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| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-4a44020d4dfe4da492036d824b80bc0e2024-01-07T12:54:31ZengBMCReproductive Biology and Endocrinology1477-78272024-01-012211910.1186/s12958-023-01171-wThe association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016Xiangpeng Zhan0Yang Liu1Tao Chen2Hao Wan3Situ Xiong4Sheng Li5Xinxi Deng6Luyao Chen7Bin Fu8Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Urology, Jiu Jiang first People’s HospitalDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Background This study aimed to investigate the relationship between serum testosterone levels and the risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link between serum testosterone and cardiovascular health, but the findings have been inconclusive. Methods This study was cross-sectional, and the data were obtained from the 2011–2016 cycle of the National Health and Nutrition Examination Survey (NHANES), which included a sample of 6,841 male participants. Serum testosterone levels were measured using a standardized assay, and CHF status was assessed through self-reporting. Covariates such as age, ethnicity, lifestyle factors, and health conditions were considered in the analysis. Results Among the participants, 242 individuals had a documented history of CHF. We observed a linear correlation between serum testosterone levels and CHF occurrence, with higher serum testosterone levels associated with a decreased risk of CHF (Q4 vs. Q1, OR = 0.29, 95% CI: 0.19–0.47, P < 0.001). After adjusting for confounding variables, multivariate analysis revealed that high serum testosterone levels remained significantly associated with a lower risk of CHF (OR: 0.47, 95% CI: 0.27–0.80, P = 0.01). Subgroup analysis indicated a significant association between high serum testosterone levels and reduced CHF risk in individuals over 50 years old. Conclusion Our findings suggest that the serum testosterone level was positively associated with CHF in adult males. This study highlights the potential role of serum testosterone in cardiovascular health, particularly in older individuals. Further research is needed to elucidate the underlying mechanisms and explore the clinical implications of these findings.https://doi.org/10.1186/s12958-023-01171-wTestosterone levelCongestive heart failureNHANESAssociationPrognostic factors |
| spellingShingle | Xiangpeng Zhan Yang Liu Tao Chen Hao Wan Situ Xiong Sheng Li Xinxi Deng Luyao Chen Bin Fu The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 Reproductive Biology and Endocrinology Testosterone level Congestive heart failure NHANES Association Prognostic factors |
| title | The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 |
| title_full | The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 |
| title_fullStr | The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 |
| title_full_unstemmed | The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 |
| title_short | The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 |
| title_sort | association between serum testosterone level and congestive heart failure in us male adults data from national health and nutrition examination survey nhanes 2011 2016 |
| topic | Testosterone level Congestive heart failure NHANES Association Prognostic factors |
| url | https://doi.org/10.1186/s12958-023-01171-w |
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