Pharmacokinetic Characterization of the DDAH1 Inhibitors ZST316 and ZST152 in Mice Using a HPLC-MS/MS Method

Pharmacokinetic Characterization of the DDAH1 Inhibitors ZST316 and ZST152 in Mice Using a HPLC-MS/MS Method

The pharmacokinetic profile of ZST316 and ZST152, arginine analogues with inhibitory activity towards human dimethylarginine dimethylaminohydrolase-1 (DDAH1), was investigated in mice using a newly developed HPLC-MS/MS method. The method proved to be reproducible, precise, and accurate for the measu...

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Bibliographic Details
Main Authors: Arduino A. Mangoni, Tommaso Ceruti, Roberta Frapolli, Massimo Russo, Stefania Fichera, Massimo Zucchetti, Sara Tommasi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
dimethylarginine dimethylaminohydrolase-1 inhibitors
ZST316
ZST152
pharmacokinetics
safety
mice
Online Access:https://www.mdpi.com/1420-3049/27/3/1017

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