Skeletal muscle in health and disease
Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (i.e. they are no longer able to divide) and perform muscle contraction. They are formed by fusion of muscle precursor cells, and grow into elongating myofibres by the addition of further precursor cells, called satellit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2020-02-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/13/2/dmm042192 |
| _version_ | 1818546888253636608 |
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| author | Jennifer Morgan Terence Partridge |
| author_facet | Jennifer Morgan Terence Partridge |
| author_sort | Jennifer Morgan |
| collection | DOAJ |
| description | Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (i.e. they are no longer able to divide) and perform muscle contraction. They are formed by fusion of muscle precursor cells, and grow into elongating myofibres by the addition of further precursor cells, called satellite cells, which are also responsible for regeneration following injury. Skeletal muscle regeneration occurs in most muscular dystrophies in response to necrosis of muscle fibres. However, the complex environment within dystrophic skeletal muscle, which includes inflammatory cells, fibroblasts and fibro-adipogenic cells, together with the genetic background of the in vivo model and the muscle being studied, complicates the interpretation of laboratory studies on muscular dystrophies. Many genes are expressed in satellite cells and in other tissues, which makes it difficult to determine the molecular cause of various types of muscular dystrophies. Here, and in the accompanying poster, we discuss our current knowledge of the cellular mechanisms that govern the growth and regeneration of skeletal muscle, and highlight the defects in satellite cell function that give rise to muscular dystrophies. |
| first_indexed | 2024-12-12T07:59:15Z |
| format | Article |
| id | doaj.art-4a48452f1ff7458baefbfabec8c81547 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-12T07:59:15Z |
| publishDate | 2020-02-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-4a48452f1ff7458baefbfabec8c815472022-12-22T00:32:12ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112020-02-0113210.1242/dmm.042192042192Skeletal muscle in health and diseaseJennifer Morgan0Terence Partridge1 Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (i.e. they are no longer able to divide) and perform muscle contraction. They are formed by fusion of muscle precursor cells, and grow into elongating myofibres by the addition of further precursor cells, called satellite cells, which are also responsible for regeneration following injury. Skeletal muscle regeneration occurs in most muscular dystrophies in response to necrosis of muscle fibres. However, the complex environment within dystrophic skeletal muscle, which includes inflammatory cells, fibroblasts and fibro-adipogenic cells, together with the genetic background of the in vivo model and the muscle being studied, complicates the interpretation of laboratory studies on muscular dystrophies. Many genes are expressed in satellite cells and in other tissues, which makes it difficult to determine the molecular cause of various types of muscular dystrophies. Here, and in the accompanying poster, we discuss our current knowledge of the cellular mechanisms that govern the growth and regeneration of skeletal muscle, and highlight the defects in satellite cell function that give rise to muscular dystrophies.http://dmm.biologists.org/content/13/2/dmm042192muscular dystrophysatellite cellskeletal muscle regeneration |
| spellingShingle | Jennifer Morgan Terence Partridge Skeletal muscle in health and disease Disease Models & Mechanisms muscular dystrophy satellite cell skeletal muscle regeneration |
| title | Skeletal muscle in health and disease |
| title_full | Skeletal muscle in health and disease |
| title_fullStr | Skeletal muscle in health and disease |
| title_full_unstemmed | Skeletal muscle in health and disease |
| title_short | Skeletal muscle in health and disease |
| title_sort | skeletal muscle in health and disease |
| topic | muscular dystrophy satellite cell skeletal muscle regeneration |
| url | http://dmm.biologists.org/content/13/2/dmm042192 |
| work_keys_str_mv | AT jennifermorgan skeletalmuscleinhealthanddisease AT terencepartridge skeletalmuscleinhealthanddisease |