Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting about 7–10 million patients worldwide. The major pathological features of PD include loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain and th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00246/full |
| _version_ | 1818132899502751744 |
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| author | Yaqi Ding Chenqi Xin Cheng-Wu Zhang Kah-Leong Lim Kah-Leong Lim Hang Zhang ZhenQian Fu Lin Li Wei Huang |
| author_facet | Yaqi Ding Chenqi Xin Cheng-Wu Zhang Kah-Leong Lim Kah-Leong Lim Hang Zhang ZhenQian Fu Lin Li Wei Huang |
| author_sort | Yaqi Ding |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting about 7–10 million patients worldwide. The major pathological features of PD include loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain and the presence of α-synuclein-enriched Lewy bodies. Although the mechanism underlying PD pathogenesis remains to be elucidated, oxidative stress induced by the overproduction of reactive oxygen species (ROS) is widely accepted to be a key pathogenic factors. ROS cause oxidative damage to proteins, lipids, and DNA, which subsequently lead to neurodegeneration. Great efforts have been made to slow or stop the progress of PD. Unfortunately there is no effective cure for PD till now. Compounds with good antioxidant activity represent the promising candidates for therapeutics of PD. Some natural molecules from Chinese herbs are found to have good antioxidant activity. Both in vitro and in vivo studies demonstrate that these natural molecules could mitigate the oxidative stress and rescue the neuronal cell death in PD models. In present review, we summarized the reported natural molecules that displayed protective effects in PD. We also addressed the possible signal pathway through which natural molecules achieved their antioxidative effects and mitigate PD phenotypes. Hopefully it will pave the way to better recognize and utilize Chinese herbs for the treatment of PD. |
| first_indexed | 2024-12-11T08:44:10Z |
| format | Article |
| id | doaj.art-4a49b63329ca4ddcac751bdfac65906a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T08:44:10Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4a49b63329ca4ddcac751bdfac65906a2022-12-22T01:14:11ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-08-011010.3389/fnagi.2018.00246345170Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative StressYaqi Ding0Chenqi Xin1Cheng-Wu Zhang2Kah-Leong Lim3Kah-Leong Lim4Hang Zhang5ZhenQian Fu6Lin Li7Wei Huang8Key Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaNeurodegeneration Research Laboratory, National Neuroscience Institute, Singapore, SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaKey Laboratory of Flexible Electronics – Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, ChinaParkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting about 7–10 million patients worldwide. The major pathological features of PD include loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain and the presence of α-synuclein-enriched Lewy bodies. Although the mechanism underlying PD pathogenesis remains to be elucidated, oxidative stress induced by the overproduction of reactive oxygen species (ROS) is widely accepted to be a key pathogenic factors. ROS cause oxidative damage to proteins, lipids, and DNA, which subsequently lead to neurodegeneration. Great efforts have been made to slow or stop the progress of PD. Unfortunately there is no effective cure for PD till now. Compounds with good antioxidant activity represent the promising candidates for therapeutics of PD. Some natural molecules from Chinese herbs are found to have good antioxidant activity. Both in vitro and in vivo studies demonstrate that these natural molecules could mitigate the oxidative stress and rescue the neuronal cell death in PD models. In present review, we summarized the reported natural molecules that displayed protective effects in PD. We also addressed the possible signal pathway through which natural molecules achieved their antioxidative effects and mitigate PD phenotypes. Hopefully it will pave the way to better recognize and utilize Chinese herbs for the treatment of PD.https://www.frontiersin.org/article/10.3389/fnagi.2018.00246/fullParkinson’s diseasedopaminergic neuronsoxidative stressnatural moleculesChinese herb |
| spellingShingle | Yaqi Ding Chenqi Xin Cheng-Wu Zhang Kah-Leong Lim Kah-Leong Lim Hang Zhang ZhenQian Fu Lin Li Wei Huang Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress Frontiers in Aging Neuroscience Parkinson’s disease dopaminergic neurons oxidative stress natural molecules Chinese herb |
| title | Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress |
| title_full | Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress |
| title_fullStr | Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress |
| title_full_unstemmed | Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress |
| title_short | Natural Molecules From Chinese Herbs Protecting Against Parkinson’s Disease via Anti-oxidative Stress |
| title_sort | natural molecules from chinese herbs protecting against parkinson s disease via anti oxidative stress |
| topic | Parkinson’s disease dopaminergic neurons oxidative stress natural molecules Chinese herb |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00246/full |
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