Construction of humanized chimeric mice with Tet-on regulating liver specific expression of uPA using CRISPR/Cas9 technology
Objective To construct NOD-SCID transgenic mice with Tet-on regulated liver specific expression of urokinase plasmin activator (uPA), repair subacute liver injury in mice through human liver cancer cell transplantation, and thereby establish humanized liver cell chimeric mice. Methods With CRISPR/Ca...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Army Medical University
2023-07-01
|
| Series: | 陆军军医大学学报 |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/html/202303025.htm |