Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects
Abstract Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19-related mortality and morbidity. So f...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-021-02542-z |
| _version_ | 1818600662622011392 |
|---|---|
| author | Mai Abdelgawad Nourhan Saied Bakry Ahmed A. Farghali Ahmed Abdel-Latif Ahmed Lotfy |
| author_facet | Mai Abdelgawad Nourhan Saied Bakry Ahmed A. Farghali Ahmed Abdel-Latif Ahmed Lotfy |
| author_sort | Mai Abdelgawad |
| collection | DOAJ |
| description | Abstract Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19-related mortality and morbidity. So far, no therapies have succeeded in circumventing the exacerbated immune response or cytokine storm associated with COVID-19. Mesenchymal stem cells (MSCs), through their immunomodulatory and regenerative activities, mostly mediated by their paracrine effect and extracellular vesicle production, have therapeutic potential in many autoimmune, inflammatory, and degenerative diseases. In this paper, we review clinical studies on the use of MSCs for COVID-19 treatment, including the salutary effects of MSCs on the pathophysiology of COVID-19 and the immunomodulation of the cytokine storm. Ongoing clinical trial designs, cell sources, dose and administration, and populations are summarized, and the paracrine mode of benefit is discussed. We also offer suggestions for optimizing MSC-based therapies, including genetic engineering, strategies for cell surface modification, nanotechnology applications, and combination therapies. |
| first_indexed | 2024-12-16T12:39:03Z |
| format | Article |
| id | doaj.art-4a4a5332c27f421886fbbbe93eb38728 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-16T12:39:03Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-4a4a5332c27f421886fbbbe93eb387282022-12-21T22:31:28ZengBMCStem Cell Research & Therapy1757-65122021-08-0112112010.1186/s13287-021-02542-zMesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospectsMai Abdelgawad0Nourhan Saied Bakry1Ahmed A. Farghali2Ahmed Abdel-Latif3Ahmed Lotfy4Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef UniversityBiotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef UniversityMaterials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef UniversityGill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky and the Lexington VA Medical CenterBiotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef UniversityAbstract Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19-related mortality and morbidity. So far, no therapies have succeeded in circumventing the exacerbated immune response or cytokine storm associated with COVID-19. Mesenchymal stem cells (MSCs), through their immunomodulatory and regenerative activities, mostly mediated by their paracrine effect and extracellular vesicle production, have therapeutic potential in many autoimmune, inflammatory, and degenerative diseases. In this paper, we review clinical studies on the use of MSCs for COVID-19 treatment, including the salutary effects of MSCs on the pathophysiology of COVID-19 and the immunomodulation of the cytokine storm. Ongoing clinical trial designs, cell sources, dose and administration, and populations are summarized, and the paracrine mode of benefit is discussed. We also offer suggestions for optimizing MSC-based therapies, including genetic engineering, strategies for cell surface modification, nanotechnology applications, and combination therapies.https://doi.org/10.1186/s13287-021-02542-zMesenchymal stem cellMesenchymal stromal cellExosomesCOVID-19ImmunomodulationCytokine storm |
| spellingShingle | Mai Abdelgawad Nourhan Saied Bakry Ahmed A. Farghali Ahmed Abdel-Latif Ahmed Lotfy Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects Stem Cell Research & Therapy Mesenchymal stem cell Mesenchymal stromal cell Exosomes COVID-19 Immunomodulation Cytokine storm |
| title | Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects |
| title_full | Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects |
| title_fullStr | Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects |
| title_full_unstemmed | Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects |
| title_short | Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects |
| title_sort | mesenchymal stem cell based therapy and exosomes in covid 19 current trends and prospects |
| topic | Mesenchymal stem cell Mesenchymal stromal cell Exosomes COVID-19 Immunomodulation Cytokine storm |
| url | https://doi.org/10.1186/s13287-021-02542-z |
| work_keys_str_mv | AT maiabdelgawad mesenchymalstemcellbasedtherapyandexosomesincovid19currenttrendsandprospects AT nourhansaiedbakry mesenchymalstemcellbasedtherapyandexosomesincovid19currenttrendsandprospects AT ahmedafarghali mesenchymalstemcellbasedtherapyandexosomesincovid19currenttrendsandprospects AT ahmedabdellatif mesenchymalstemcellbasedtherapyandexosomesincovid19currenttrendsandprospects AT ahmedlotfy mesenchymalstemcellbasedtherapyandexosomesincovid19currenttrendsandprospects |