Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy
Receptor tyrosine kinases (RTKs) regulate critical physiological processes, such as cell growth, survival, motility, and metabolism. Abnormal activation of RTKs and relative downstream signaling is implicated in cancer pathogenesis. Phage display allows the rapid selection of peptide ligands of memb...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/4/649 |
| _version_ | 1797538180405133312 |
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| author | Annamaria Aloisio Nancy Nisticò Selena Mimmi Domenico Maisano Eleonora Vecchio Giuseppe Fiume Enrico Iaccino Ileana Quinto |
| author_facet | Annamaria Aloisio Nancy Nisticò Selena Mimmi Domenico Maisano Eleonora Vecchio Giuseppe Fiume Enrico Iaccino Ileana Quinto |
| author_sort | Annamaria Aloisio |
| collection | DOAJ |
| description | Receptor tyrosine kinases (RTKs) regulate critical physiological processes, such as cell growth, survival, motility, and metabolism. Abnormal activation of RTKs and relative downstream signaling is implicated in cancer pathogenesis. Phage display allows the rapid selection of peptide ligands of membrane receptors. These peptides can target in vitro and in vivo tumor cells and represent a novel therapeutic approach for cancer therapy. Further, they are more convenient compared to antibodies, being less expensive and non-immunogenic. In this review, we describe the state-of-the-art of phage display for development of peptide ligands of tyrosine kinase membrane receptors and discuss their potential applications for tumor-targeted therapy. |
| first_indexed | 2024-03-10T12:27:52Z |
| format | Article |
| id | doaj.art-4a4a8149f9b24b979bf97d500f11815e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:27:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4a4a8149f9b24b979bf97d500f11815e2023-11-21T14:53:41ZengMDPI AGViruses1999-49152021-04-0113464910.3390/v13040649Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer TherapyAnnamaria Aloisio0Nancy Nisticò1Selena Mimmi2Domenico Maisano3Eleonora Vecchio4Giuseppe Fiume5Enrico Iaccino6Ileana Quinto7Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyReceptor tyrosine kinases (RTKs) regulate critical physiological processes, such as cell growth, survival, motility, and metabolism. Abnormal activation of RTKs and relative downstream signaling is implicated in cancer pathogenesis. Phage display allows the rapid selection of peptide ligands of membrane receptors. These peptides can target in vitro and in vivo tumor cells and represent a novel therapeutic approach for cancer therapy. Further, they are more convenient compared to antibodies, being less expensive and non-immunogenic. In this review, we describe the state-of-the-art of phage display for development of peptide ligands of tyrosine kinase membrane receptors and discuss their potential applications for tumor-targeted therapy.https://www.mdpi.com/1999-4915/13/4/649phage displaypeptide ligandstyrosine kinase receptorstumor-targeting |
| spellingShingle | Annamaria Aloisio Nancy Nisticò Selena Mimmi Domenico Maisano Eleonora Vecchio Giuseppe Fiume Enrico Iaccino Ileana Quinto Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy Viruses phage display peptide ligands tyrosine kinase receptors tumor-targeting |
| title | Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy |
| title_full | Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy |
| title_fullStr | Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy |
| title_full_unstemmed | Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy |
| title_short | Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy |
| title_sort | phage displayed peptides for targeting tyrosine kinase membrane receptors in cancer therapy |
| topic | phage display peptide ligands tyrosine kinase receptors tumor-targeting |
| url | https://www.mdpi.com/1999-4915/13/4/649 |
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