An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation
The peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corresponding receptors on immune cells implies an esse...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.679055/full |
| _version_ | 1818650896832135168 |
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| author | Manuel O. Jakob Michael Kofoed-Branzk Divija Deshpande Shaira Murugan Christoph S. N. Klose |
| author_facet | Manuel O. Jakob Michael Kofoed-Branzk Divija Deshpande Shaira Murugan Christoph S. N. Klose |
| author_sort | Manuel O. Jakob |
| collection | DOAJ |
| description | The peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corresponding receptors on immune cells implies an essential role for the nervous system in regulating immune reactions. Vice versa, neurons express functional cytokine receptors to respond to inflammatory signals directly. Recent advances in single-cell and single-nuclei sequencing have provided an unprecedented depth in neuronal analysis and allowed to refine the classification of distinct neuronal subsets of the peripheral nervous system. Delineating the sensory and immunoregulatory capacity of different neuronal subsets could inform a better understanding of the response happening in tissues that coordinate physiologic functions, tissue homeostasis and immunity. Here, we summarize current subsets of peripheral neurons and discuss neuronal regulation of immune responses, focusing on neuro-immune interactions in the gastrointestinal tract. The nervous system as a central coordinator of immune reactions and tissue homeostasis may predispose for novel promising therapeutic approaches for a large variety of diseases including but not limited to chronic inflammation. |
| first_indexed | 2024-12-17T01:57:30Z |
| format | Article |
| id | doaj.art-4a4b1e49cc6e48cab0b080c54cbdc743 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T01:57:30Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4a4b1e49cc6e48cab0b080c54cbdc7432022-12-21T22:07:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.679055679055An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in ImmunoregulationManuel O. Jakob0Michael Kofoed-Branzk1Divija Deshpande2Shaira Murugan3Christoph S. N. Klose4Department of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of BioMedical Research, Group of Visceral Surgery and Medicine, University of Bern, Bern, SwitzerlandDepartment of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyThe peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corresponding receptors on immune cells implies an essential role for the nervous system in regulating immune reactions. Vice versa, neurons express functional cytokine receptors to respond to inflammatory signals directly. Recent advances in single-cell and single-nuclei sequencing have provided an unprecedented depth in neuronal analysis and allowed to refine the classification of distinct neuronal subsets of the peripheral nervous system. Delineating the sensory and immunoregulatory capacity of different neuronal subsets could inform a better understanding of the response happening in tissues that coordinate physiologic functions, tissue homeostasis and immunity. Here, we summarize current subsets of peripheral neurons and discuss neuronal regulation of immune responses, focusing on neuro-immune interactions in the gastrointestinal tract. The nervous system as a central coordinator of immune reactions and tissue homeostasis may predispose for novel promising therapeutic approaches for a large variety of diseases including but not limited to chronic inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2021.679055/fullneuro-immune interactionsneuronal classificationperipheral nervous systementeric nervous systemdorsal root ganglia (DRG)function of neurons |
| spellingShingle | Manuel O. Jakob Michael Kofoed-Branzk Divija Deshpande Shaira Murugan Christoph S. N. Klose An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation Frontiers in Immunology neuro-immune interactions neuronal classification peripheral nervous system enteric nervous system dorsal root ganglia (DRG) function of neurons |
| title | An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation |
| title_full | An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation |
| title_fullStr | An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation |
| title_full_unstemmed | An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation |
| title_short | An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation |
| title_sort | integrated view on neuronal subsets in the peripheral nervous system and their role in immunoregulation |
| topic | neuro-immune interactions neuronal classification peripheral nervous system enteric nervous system dorsal root ganglia (DRG) function of neurons |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.679055/full |
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