Epidemic keratoconjunctivitis: A review of current concepts in management
Epidemic keratoconjunctivitis (EKC) is an ocular surface infection caused by adenovirus. To date, there are no approved topical antiadenoviral therapeutics to treat EKC. Recent research reveals that treatment with topical corticosteroids for symptomatic relief of EKC enhances adenovirus replication...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-04-01
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| Series: | Journal of Optometry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1888429612000921 |
| _version_ | 1818970203346698240 |
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| author | Andria M. Pihos |
| author_facet | Andria M. Pihos |
| author_sort | Andria M. Pihos |
| collection | DOAJ |
| description | Epidemic keratoconjunctivitis (EKC) is an ocular surface infection caused by adenovirus. To date, there are no approved topical antiadenoviral therapeutics to treat EKC. Recent research reveals that treatment with topical corticosteroids for symptomatic relief of EKC enhances adenovirus replication and delays cell shedding from the ocular surface which delays adenovirus elimination. The current management of EKC largely revolves around accurate diagnosis of the condition and implementation of disinfection protocol to prevent its spread. Development of an effective antiviral treatment that addresses inflammation and does not prolong viral shedding would provide significant benefit. The literature reports on a variety of therapeutics that could potentially satisfy this deficiency. Topical ganciclovir and povidone-iodine combination drops have shown the most recent potential, but both therapeutics need to be investigated in larger scale studies. Until an antiadenoviral option is produced, the treatment of EKC should maintain a judicious case by case approach aiming to contain its dissemination and prevent visual consequences. |
| first_indexed | 2024-12-20T14:32:45Z |
| format | Article |
| id | doaj.art-4a4be26ed14f4da6935c868088bc7c9a |
| institution | Directory Open Access Journal |
| issn | 1888-4296 |
| language | English |
| last_indexed | 2024-12-20T14:32:45Z |
| publishDate | 2013-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Optometry |
| spelling | doaj.art-4a4be26ed14f4da6935c868088bc7c9a2022-12-21T19:37:34ZengElsevierJournal of Optometry1888-42962013-04-0162697410.1016/j.optom.2012.08.003Epidemic keratoconjunctivitis: A review of current concepts in managementAndria M. PihosEpidemic keratoconjunctivitis (EKC) is an ocular surface infection caused by adenovirus. To date, there are no approved topical antiadenoviral therapeutics to treat EKC. Recent research reveals that treatment with topical corticosteroids for symptomatic relief of EKC enhances adenovirus replication and delays cell shedding from the ocular surface which delays adenovirus elimination. The current management of EKC largely revolves around accurate diagnosis of the condition and implementation of disinfection protocol to prevent its spread. Development of an effective antiviral treatment that addresses inflammation and does not prolong viral shedding would provide significant benefit. The literature reports on a variety of therapeutics that could potentially satisfy this deficiency. Topical ganciclovir and povidone-iodine combination drops have shown the most recent potential, but both therapeutics need to be investigated in larger scale studies. Until an antiadenoviral option is produced, the treatment of EKC should maintain a judicious case by case approach aiming to contain its dissemination and prevent visual consequences.http://www.sciencedirect.com/science/article/pii/S1888429612000921AdenovirusEpidemic keratoconjunctivitisPseudomembraneSubepithelial infiltratesAdenovirus shedding |
| spellingShingle | Andria M. Pihos Epidemic keratoconjunctivitis: A review of current concepts in management Journal of Optometry Adenovirus Epidemic keratoconjunctivitis Pseudomembrane Subepithelial infiltrates Adenovirus shedding |
| title | Epidemic keratoconjunctivitis: A review of current concepts in management |
| title_full | Epidemic keratoconjunctivitis: A review of current concepts in management |
| title_fullStr | Epidemic keratoconjunctivitis: A review of current concepts in management |
| title_full_unstemmed | Epidemic keratoconjunctivitis: A review of current concepts in management |
| title_short | Epidemic keratoconjunctivitis: A review of current concepts in management |
| title_sort | epidemic keratoconjunctivitis a review of current concepts in management |
| topic | Adenovirus Epidemic keratoconjunctivitis Pseudomembrane Subepithelial infiltrates Adenovirus shedding |
| url | http://www.sciencedirect.com/science/article/pii/S1888429612000921 |
| work_keys_str_mv | AT andriampihos epidemickeratoconjunctivitisareviewofcurrentconceptsinmanagement |