Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?
Human pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSC-derived CMs have been developed. Most of them utilize the modulation of human cardiomy...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2015-03-01
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| Series: | BioDiscovery |
| Online Access: | https://biodiscovery.pensoft.net/article/8968/download/pdf/ |
| _version_ | 1818936023527194624 |
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| author | Dimitar Trifonov |
| author_facet | Dimitar Trifonov |
| author_sort | Dimitar Trifonov |
| collection | DOAJ |
| description | Human pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSC-derived CMs have been developed. Most of them utilize the modulation of human cardiomyogenesis via small-molecule compounds. However, setbacks to the large-scale application of hPSC-derived CMs still abound: insufficient insight into important signaling pathways for cardiac lineage-specific differentiation and identification of suitable small-molecule modulators; inconsistent results due to unstandardised culturing techniques; lack of effective maturation of hPSC-derived CMs in vitro. So is there a bottleneck in current research? This paper attempts to answer this question. |
| first_indexed | 2024-12-20T05:29:28Z |
| format | Article |
| id | doaj.art-4a4c3928023045738776a94a8d745604 |
| institution | Directory Open Access Journal |
| issn | 2050-2966 |
| language | English |
| last_indexed | 2024-12-20T05:29:28Z |
| publishDate | 2015-03-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | BioDiscovery |
| spelling | doaj.art-4a4c3928023045738776a94a8d7456042022-12-21T19:51:47ZengPensoft PublishersBioDiscovery2050-29662015-03-01151610.7750/BioDiscovery.2015.15.28968Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?Dimitar TrifonovHuman pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSC-derived CMs have been developed. Most of them utilize the modulation of human cardiomyogenesis via small-molecule compounds. However, setbacks to the large-scale application of hPSC-derived CMs still abound: insufficient insight into important signaling pathways for cardiac lineage-specific differentiation and identification of suitable small-molecule modulators; inconsistent results due to unstandardised culturing techniques; lack of effective maturation of hPSC-derived CMs in vitro. So is there a bottleneck in current research? This paper attempts to answer this question.https://biodiscovery.pensoft.net/article/8968/download/pdf/ |
| spellingShingle | Dimitar Trifonov Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? BioDiscovery |
| title | Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? |
| title_full | Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? |
| title_fullStr | Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? |
| title_full_unstemmed | Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? |
| title_short | Small molecules and human cardiomyogenesis: Is there a bottleneck in current research? |
| title_sort | small molecules and human cardiomyogenesis is there a bottleneck in current research |
| url | https://biodiscovery.pensoft.net/article/8968/download/pdf/ |
| work_keys_str_mv | AT dimitartrifonov smallmoleculesandhumancardiomyogenesisisthereabottleneckincurrentresearch |