Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review
Inflammatory bowel disease (IBD) is a chronic disease for which medical treatment with immunomodulating drugs is increasingly used earlier to prevent disability. Additionally, cancer occurrence in IBD patients is increased for several reasons, either IBD-related or therapy-associated. Doctors are th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/12/3130 |
| _version_ | 1797436126976278528 |
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| author | Daniel Conceição Margarida R. Saraiva Isadora Rosa Isabel Claro |
| author_facet | Daniel Conceição Margarida R. Saraiva Isadora Rosa Isabel Claro |
| author_sort | Daniel Conceição |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic disease for which medical treatment with immunomodulating drugs is increasingly used earlier to prevent disability. Additionally, cancer occurrence in IBD patients is increased for several reasons, either IBD-related or therapy-associated. Doctors are therefore facing the challenge of managing patients with IBD and a past or current malignancy and the need to balance the risk of cancer recurrence associated with immunosuppressive drugs with the potential worsening of IBD activity if they are withdrawn. This review aims to explore the features of different subtypes of cancer occurring in IBD patients to present current evidence on malignancy recurrence risk associated with IBD medical therapy along with the effects of cancer treatment in IBD and finally to discuss current recommendations on the management of these patients. Due to sparse data, a case-by-case multidisciplinary discussion is advised, including inputs from the gastroenterologist, oncologist, and patient. |
| first_indexed | 2024-03-09T10:58:04Z |
| format | Article |
| id | doaj.art-4a4daa404c574e8e8ccc4746a0754e20 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:58:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4a4daa404c574e8e8ccc4746a0754e202023-12-01T01:30:38ZengMDPI AGCancers2072-66942023-06-011512313010.3390/cancers15123130Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive ReviewDaniel Conceição0Margarida R. Saraiva1Isadora Rosa2Isabel Claro3Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisboa, PortugalDepartment of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisboa, PortugalDepartment of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisboa, PortugalDepartment of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisboa, PortugalInflammatory bowel disease (IBD) is a chronic disease for which medical treatment with immunomodulating drugs is increasingly used earlier to prevent disability. Additionally, cancer occurrence in IBD patients is increased for several reasons, either IBD-related or therapy-associated. Doctors are therefore facing the challenge of managing patients with IBD and a past or current malignancy and the need to balance the risk of cancer recurrence associated with immunosuppressive drugs with the potential worsening of IBD activity if they are withdrawn. This review aims to explore the features of different subtypes of cancer occurring in IBD patients to present current evidence on malignancy recurrence risk associated with IBD medical therapy along with the effects of cancer treatment in IBD and finally to discuss current recommendations on the management of these patients. Due to sparse data, a case-by-case multidisciplinary discussion is advised, including inputs from the gastroenterologist, oncologist, and patient.https://www.mdpi.com/2072-6694/15/12/3130inflammatory bowel diseasemalignancyimmunomodulationcancer recurrence |
| spellingShingle | Daniel Conceição Margarida R. Saraiva Isadora Rosa Isabel Claro Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review Cancers inflammatory bowel disease malignancy immunomodulation cancer recurrence |
| title | Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review |
| title_full | Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review |
| title_fullStr | Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review |
| title_full_unstemmed | Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review |
| title_short | Inflammatory Bowel Disease Treatment in Cancer Patients—A Comprehensive Review |
| title_sort | inflammatory bowel disease treatment in cancer patients a comprehensive review |
| topic | inflammatory bowel disease malignancy immunomodulation cancer recurrence |
| url | https://www.mdpi.com/2072-6694/15/12/3130 |
| work_keys_str_mv | AT danielconceicao inflammatoryboweldiseasetreatmentincancerpatientsacomprehensivereview AT margaridarsaraiva inflammatoryboweldiseasetreatmentincancerpatientsacomprehensivereview AT isadorarosa inflammatoryboweldiseasetreatmentincancerpatientsacomprehensivereview AT isabelclaro inflammatoryboweldiseasetreatmentincancerpatientsacomprehensivereview |