SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20653-8 |
| _version_ | 1818858157027360768 |
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| author | Jing-Hui Tian Nita Patel Robert Haupt Haixia Zhou Stuart Weston Holly Hammond James Logue Alyse D. Portnoff James Norton Mimi Guebre-Xabier Bin Zhou Kelsey Jacobson Sonia Maciejewski Rafia Khatoon Malgorzata Wisniewska Will Moffitt Stefanie Kluepfel-Stahl Betty Ekechukwu James Papin Sarathi Boddapati C. Jason Wong Pedro A. Piedra Matthew B. Frieman Michael J. Massare Louis Fries Karin Lövgren Bengtsson Linda Stertman Larry Ellingsworth Gregory Glenn Gale Smith |
| author_facet | Jing-Hui Tian Nita Patel Robert Haupt Haixia Zhou Stuart Weston Holly Hammond James Logue Alyse D. Portnoff James Norton Mimi Guebre-Xabier Bin Zhou Kelsey Jacobson Sonia Maciejewski Rafia Khatoon Malgorzata Wisniewska Will Moffitt Stefanie Kluepfel-Stahl Betty Ekechukwu James Papin Sarathi Boddapati C. Jason Wong Pedro A. Piedra Matthew B. Frieman Michael J. Massare Louis Fries Karin Lövgren Bengtsson Linda Stertman Larry Ellingsworth Gregory Glenn Gale Smith |
| author_sort | Jing-Hui Tian |
| collection | DOAJ |
| description | Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine. |
| first_indexed | 2024-12-19T08:51:49Z |
| format | Article |
| id | doaj.art-4a4e382fc93a4e5c84f3c4b94fc40a65 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:51:49Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4a4e382fc93a4e5c84f3c4b94fc40a652022-12-21T20:28:42ZengNature PortfolioNature Communications2041-17232021-01-0112111410.1038/s41467-020-20653-8SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in miceJing-Hui Tian0Nita Patel1Robert Haupt2Haixia Zhou3Stuart Weston4Holly Hammond5James Logue6Alyse D. Portnoff7James Norton8Mimi Guebre-Xabier9Bin Zhou10Kelsey Jacobson11Sonia Maciejewski12Rafia Khatoon13Malgorzata Wisniewska14Will Moffitt15Stefanie Kluepfel-Stahl16Betty Ekechukwu17James Papin18Sarathi Boddapati19C. Jason Wong20Pedro A. Piedra21Matthew B. Frieman22Michael J. Massare23Louis Fries24Karin Lövgren Bengtsson25Linda Stertman26Larry Ellingsworth27Gregory Glenn28Gale Smith29Novavax, Inc.Novavax, Inc.University of Maryland, School of MedicineNovavax, Inc.University of Maryland, School of MedicineUniversity of Maryland, School of MedicineUniversity of Maryland, School of MedicineNovavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Novavax, Inc.Department of Pathology, Division of Comparative Medicine, University of Oklahoma, Health Sciences CenterCatalent Cell & Gene TherapyCatalent Cell & Gene TherapyDepartment of Molecular Virology and Microbiology, and Pediatrics, Baylor College of MedicineUniversity of Maryland, School of MedicineNovavax, Inc.Novavax, Inc.Novavax ABNovavax ABNovavax, Inc.Novavax, Inc.Novavax, Inc.Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.https://doi.org/10.1038/s41467-020-20653-8 |
| spellingShingle | Jing-Hui Tian Nita Patel Robert Haupt Haixia Zhou Stuart Weston Holly Hammond James Logue Alyse D. Portnoff James Norton Mimi Guebre-Xabier Bin Zhou Kelsey Jacobson Sonia Maciejewski Rafia Khatoon Malgorzata Wisniewska Will Moffitt Stefanie Kluepfel-Stahl Betty Ekechukwu James Papin Sarathi Boddapati C. Jason Wong Pedro A. Piedra Matthew B. Frieman Michael J. Massare Louis Fries Karin Lövgren Bengtsson Linda Stertman Larry Ellingsworth Gregory Glenn Gale Smith SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice Nature Communications |
| title | SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice |
| title_full | SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice |
| title_fullStr | SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice |
| title_full_unstemmed | SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice |
| title_short | SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice |
| title_sort | sars cov 2 spike glycoprotein vaccine candidate nvx cov2373 immunogenicity in baboons and protection in mice |
| url | https://doi.org/10.1038/s41467-020-20653-8 |
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