Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation
Eating out of phase with daily circadian rhythms induces metabolic desynchrony in peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating (TRE) is a dietary approach that consolidates all calorie intake to 6- to 10-h periods during the active phase of the day, witho...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220303461 |
| _version_ | 1819080242572034048 |
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| author | Prashant Regmi Leonie K. Heilbronn |
| author_facet | Prashant Regmi Leonie K. Heilbronn |
| author_sort | Prashant Regmi |
| collection | DOAJ |
| description | Eating out of phase with daily circadian rhythms induces metabolic desynchrony in peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating (TRE) is a dietary approach that consolidates all calorie intake to 6- to 10-h periods during the active phase of the day, without necessarily altering diet quality and quantity. TRE reduces body weight, improves glucose tolerance, protects from hepatosteatosis, increases metabolic flexibility, reduces atherogenic lipids and blood pressure, and improves gut function and cardiometabolic health in preclinical studies. This review discusses the importance of meal timing on the circadian system, the metabolic health benefits of TRE in preclinical models and humans, the possible mechanisms of action, the challenges we face in implementing TRE in humans, and the possible consequences of delaying initiation of TRE. |
| first_indexed | 2024-12-21T19:41:46Z |
| format | Article |
| id | doaj.art-4a4e94af8c0a4698a5c03031c6704da6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T19:41:46Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-4a4e94af8c0a4698a5c03031c6704da62022-12-21T18:52:26ZengElsevieriScience2589-00422020-06-01236101161Time-Restricted Eating: Benefits, Mechanisms, and Challenges in TranslationPrashant Regmi0Leonie K. Heilbronn1Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia; Life-Long Health Research Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia; NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, SA 5000, AustraliaAdelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia; Life-Long Health Research Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia; NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, SA 5000, Australia; Corresponding authorEating out of phase with daily circadian rhythms induces metabolic desynchrony in peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating (TRE) is a dietary approach that consolidates all calorie intake to 6- to 10-h periods during the active phase of the day, without necessarily altering diet quality and quantity. TRE reduces body weight, improves glucose tolerance, protects from hepatosteatosis, increases metabolic flexibility, reduces atherogenic lipids and blood pressure, and improves gut function and cardiometabolic health in preclinical studies. This review discusses the importance of meal timing on the circadian system, the metabolic health benefits of TRE in preclinical models and humans, the possible mechanisms of action, the challenges we face in implementing TRE in humans, and the possible consequences of delaying initiation of TRE.http://www.sciencedirect.com/science/article/pii/S2589004220303461Biological SciencesChronobiologyNutrition |
| spellingShingle | Prashant Regmi Leonie K. Heilbronn Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation iScience Biological Sciences Chronobiology Nutrition |
| title | Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation |
| title_full | Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation |
| title_fullStr | Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation |
| title_full_unstemmed | Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation |
| title_short | Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation |
| title_sort | time restricted eating benefits mechanisms and challenges in translation |
| topic | Biological Sciences Chronobiology Nutrition |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220303461 |
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