A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults
Abstract Objective Molecular markers in DNA methylation at a subset of CpG sites are affected by the environment and contribute to biological (epigenetic) age. We hypothesized that shorter sleep duration and possibly irregular sleep would be associated with accelerated epigenetic aging. We examined...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4633-1 |
| _version_ | 1818851265052934144 |
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| author | Mary A. Carskadon Kenneth R. Chappell David H. Barker Anne C. Hart Kayla Dwyer Caroline Gredvig-Ardito Caitlyn Starr John E. McGeary |
| author_facet | Mary A. Carskadon Kenneth R. Chappell David H. Barker Anne C. Hart Kayla Dwyer Caroline Gredvig-Ardito Caitlyn Starr John E. McGeary |
| author_sort | Mary A. Carskadon |
| collection | DOAJ |
| description | Abstract Objective Molecular markers in DNA methylation at a subset of CpG sites are affected by the environment and contribute to biological (epigenetic) age. We hypothesized that shorter sleep duration and possibly irregular sleep would be associated with accelerated epigenetic aging. We examined epigenetic vs. chronological age in 12 young women selected as shorter or longer sleepers studied prospectively across the first 9 weeks of college using a daily online sleep log. Genomic DNA was isolated from two blood samples spanning the interval, and DNA methylation levels were determined and used to measure epigenetic age. Results Epigenetic vs. chronological age differences averaged 2.07 at Time 1 and 1.21 at Time 2. Sleep duration was computed as average daily total sleep time and sleep regularity was indexed using the Sleep Regularity Index. Participants with longer and more regular sleep showed reduced age difference: mean = − 2.48 [95% CI − 6.11; 1.15]; those with shorter and more irregular sleep showed an increased age difference: 3.03 [0.02; 6.03]; and those with either shorter or more irregular sleep averaged no significant change: − 0.49 [− 3.55; 2.56]. These pilot data suggest that short and irregular sleep, even in a young healthy sample, may be associated with accelerated epigenetic aging. |
| first_indexed | 2024-12-19T07:02:16Z |
| format | Article |
| id | doaj.art-4a50c02899884c9aa443aba543b0206e |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-19T07:02:16Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-4a50c02899884c9aa443aba543b0206e2022-12-21T20:31:23ZengBMCBMC Research Notes1756-05002019-09-011211510.1186/s13104-019-4633-1A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adultsMary A. Carskadon0Kenneth R. Chappell1David H. Barker2Anne C. Hart3Kayla Dwyer4Caroline Gredvig-Ardito5Caitlyn Starr6John E. McGeary7EP Bradley Hospital Sleep Research LaboratoryProvidence Veterans Affairs Medical CenterDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown UniversityDepartment of Neuroscience and Robert J. & Nancy D. Carney Institute for Brain Science, Brown UniversityProvidence Veterans Affairs Medical CenterEP Bradley Hospital Sleep Research LaboratoryProvidence Veterans Affairs Medical CenterDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown UniversityAbstract Objective Molecular markers in DNA methylation at a subset of CpG sites are affected by the environment and contribute to biological (epigenetic) age. We hypothesized that shorter sleep duration and possibly irregular sleep would be associated with accelerated epigenetic aging. We examined epigenetic vs. chronological age in 12 young women selected as shorter or longer sleepers studied prospectively across the first 9 weeks of college using a daily online sleep log. Genomic DNA was isolated from two blood samples spanning the interval, and DNA methylation levels were determined and used to measure epigenetic age. Results Epigenetic vs. chronological age differences averaged 2.07 at Time 1 and 1.21 at Time 2. Sleep duration was computed as average daily total sleep time and sleep regularity was indexed using the Sleep Regularity Index. Participants with longer and more regular sleep showed reduced age difference: mean = − 2.48 [95% CI − 6.11; 1.15]; those with shorter and more irregular sleep showed an increased age difference: 3.03 [0.02; 6.03]; and those with either shorter or more irregular sleep averaged no significant change: − 0.49 [− 3.55; 2.56]. These pilot data suggest that short and irregular sleep, even in a young healthy sample, may be associated with accelerated epigenetic aging.http://link.springer.com/article/10.1186/s13104-019-4633-1Sleep regularitySleep durationEpigenetic agingYoung adult |
| spellingShingle | Mary A. Carskadon Kenneth R. Chappell David H. Barker Anne C. Hart Kayla Dwyer Caroline Gredvig-Ardito Caitlyn Starr John E. McGeary A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults BMC Research Notes Sleep regularity Sleep duration Epigenetic aging Young adult |
| title | A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults |
| title_full | A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults |
| title_fullStr | A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults |
| title_full_unstemmed | A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults |
| title_short | A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults |
| title_sort | pilot prospective study of sleep patterns and dna methylation characterized epigenetic aging in young adults |
| topic | Sleep regularity Sleep duration Epigenetic aging Young adult |
| url | http://link.springer.com/article/10.1186/s13104-019-4633-1 |
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