The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report

Background and objectives: Ventricular fibrillation occurring in a patient can result in unexpected complications. Here, our aim is to present a case of ventricular fibrillation occurring immediately after anesthesia induction with etomidate administration. Case report: A fifty-six-year-old female p...

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Main Authors: Murat Karcioglu, Isil Davarci, Nuray Kirecci, Adnan Burak Akcay, Selim Turhanoglu, Kasim Tuzcu, Sedat Hakimoglu, Seckin Akkucuk, Akin Aydogan
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Brazilian Journal of Anesthesiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0104001413001486
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author Murat Karcioglu
Isil Davarci
Nuray Kirecci
Adnan Burak Akcay
Selim Turhanoglu
Kasim Tuzcu
Sedat Hakimoglu
Seckin Akkucuk
Akin Aydogan
author_facet Murat Karcioglu
Isil Davarci
Nuray Kirecci
Adnan Burak Akcay
Selim Turhanoglu
Kasim Tuzcu
Sedat Hakimoglu
Seckin Akkucuk
Akin Aydogan
author_sort Murat Karcioglu
collection DOAJ
description Background and objectives: Ventricular fibrillation occurring in a patient can result in unexpected complications. Here, our aim is to present a case of ventricular fibrillation occurring immediately after anesthesia induction with etomidate administration. Case report: A fifty-six-year-old female patient with a pre-diagnosis of gallstones was admitted to the operating room for laparoscopic cholecystectomy. The induction was performed by etomidate with a bolus dose of 0.3 mg/kg. Severe and fast adduction appeared in the patient's arms immediately after induction. A tachycardia with wide QRS and ventricular rate 188 beat/min was detected on the monitor. The rhythm turned to VF during the preparation of cardioversion. Immediately we performed defibrillation to the patient. Sinus rhythm was obtained. It was decided to postpone the operation due to the patient's unstable condition. Conclusion: In addition to other known side effects of etomidate, very rarely, ventricular tachycardia and fibrillation can be also seen. To the best of our knowledge, this is the first case regarding etomidate causing VF in the literature. Resumo: Justificativa e objetivos: A ocorrência de fibrilação ventricular em um paciente pode resultar em complicações inesperadas. Nosso objetivo é apresentar um caso de fibrilação ventricular que ocorreu após a indução anestésica com administração de etomidato. Relato de caso: Paciente do sexo feminino, 56 anos, com pré-diagnóstico de cálculos biliares, foi admitida na sala de cirurgia para colecistectomia laparoscópica. A anestesia foi induzida com a administração de etomidato com uma dose em bolus de 0,3 mg/kg. A paciente apresentou uma grave e rápida adução dos braços logo após a indução. Taquicardia com QRS largo e frequência ventricular de 188 bpm foram detectadas no monitor. O ritmo converteu-se em fibrilação ventricular (FV) durante a preparação para a cardioversão. A paciente foi imediatamente submetida a desfibrilação. O ritmo sinusal foi obtido. Decidimos adiar a cirurgia por causa da condição de instabilidade da paciente. Conclusão: Além dos efeitos secundários conhecidos de etomidato, taquicardia ventricular e fibrilação, embora muito raramente, também podem ser observadas. Até onde sabemos, esse é o primeiro caso na literatura de FV causado por etomidato. Keywords: Etomidate, Induction of anesthesia, Ventricular fibrillation, Palavras-chave: Etomidato, Indução da anestesia, Fibrilação ventricular
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spelling doaj.art-4a51bb622c3d4ba491e299b807ee5fce2022-12-22T03:51:00ZengElsevierBrazilian Journal of Anesthesiology0104-00142014-09-01645365368The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case reportMurat Karcioglu0Isil Davarci1Nuray Kirecci2Adnan Burak Akcay3Selim Turhanoglu4Kasim Tuzcu5Sedat Hakimoglu6Seckin Akkucuk7Akin Aydogan8Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey; Corresponding author.Department of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of Cardiology, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of General Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyDepartment of General Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, TurkeyBackground and objectives: Ventricular fibrillation occurring in a patient can result in unexpected complications. Here, our aim is to present a case of ventricular fibrillation occurring immediately after anesthesia induction with etomidate administration. Case report: A fifty-six-year-old female patient with a pre-diagnosis of gallstones was admitted to the operating room for laparoscopic cholecystectomy. The induction was performed by etomidate with a bolus dose of 0.3 mg/kg. Severe and fast adduction appeared in the patient's arms immediately after induction. A tachycardia with wide QRS and ventricular rate 188 beat/min was detected on the monitor. The rhythm turned to VF during the preparation of cardioversion. Immediately we performed defibrillation to the patient. Sinus rhythm was obtained. It was decided to postpone the operation due to the patient's unstable condition. Conclusion: In addition to other known side effects of etomidate, very rarely, ventricular tachycardia and fibrillation can be also seen. To the best of our knowledge, this is the first case regarding etomidate causing VF in the literature. Resumo: Justificativa e objetivos: A ocorrência de fibrilação ventricular em um paciente pode resultar em complicações inesperadas. Nosso objetivo é apresentar um caso de fibrilação ventricular que ocorreu após a indução anestésica com administração de etomidato. Relato de caso: Paciente do sexo feminino, 56 anos, com pré-diagnóstico de cálculos biliares, foi admitida na sala de cirurgia para colecistectomia laparoscópica. A anestesia foi induzida com a administração de etomidato com uma dose em bolus de 0,3 mg/kg. A paciente apresentou uma grave e rápida adução dos braços logo após a indução. Taquicardia com QRS largo e frequência ventricular de 188 bpm foram detectadas no monitor. O ritmo converteu-se em fibrilação ventricular (FV) durante a preparação para a cardioversão. A paciente foi imediatamente submetida a desfibrilação. O ritmo sinusal foi obtido. Decidimos adiar a cirurgia por causa da condição de instabilidade da paciente. Conclusão: Além dos efeitos secundários conhecidos de etomidato, taquicardia ventricular e fibrilação, embora muito raramente, também podem ser observadas. Até onde sabemos, esse é o primeiro caso na literatura de FV causado por etomidato. Keywords: Etomidate, Induction of anesthesia, Ventricular fibrillation, Palavras-chave: Etomidato, Indução da anestesia, Fibrilação ventricularhttp://www.sciencedirect.com/science/article/pii/S0104001413001486
spellingShingle Murat Karcioglu
Isil Davarci
Nuray Kirecci
Adnan Burak Akcay
Selim Turhanoglu
Kasim Tuzcu
Sedat Hakimoglu
Seckin Akkucuk
Akin Aydogan
The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
Brazilian Journal of Anesthesiology
title The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
title_full The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
title_fullStr The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
title_full_unstemmed The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
title_short The development of ventricular fibrillation due to etomidate for anesthetic induction: a very rare side effect, case report
title_sort development of ventricular fibrillation due to etomidate for anesthetic induction a very rare side effect case report
url http://www.sciencedirect.com/science/article/pii/S0104001413001486
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