High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
<p>Abstract</p> <p>Background</p> <p>Impaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes, associated with components of the metabolic syndrome. There are no data concerning fibrinolysis in subjects with normal glucose tolerance that convert...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2003-12-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/2/1/19 |
| _version_ | 1811250904605655040 |
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| author | Jansson Jan-Håkan Eliasson Mats CE Lindahl Bernt Stegmayr Birgitta |
| author_facet | Jansson Jan-Håkan Eliasson Mats CE Lindahl Bernt Stegmayr Birgitta |
| author_sort | Jansson Jan-Håkan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Impaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes, associated with components of the metabolic syndrome. There are no data concerning fibrinolysis in subjects with normal glucose tolerance that convert to diabetes.</p> <p>Methods</p> <p>We studied the activities of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) and the levels of tPA antigen (a marker of endothelial dysfunction) in 551 subjects with normal glucose tolerance in 1990 in relation to incident diabetes during nine years of follow-up.</p> <p>Results</p> <p>Subjects with diabetes at follow-up (n = 15) had significantly lower baseline tPA activity and higher PAI-1 activity and tPA antigen than non-converters. The risk of diabetes increased linearly across quartiles of PAI-activity (<it>p </it>= 0.007) and tPA antigen (<it>p </it>< 0.001) and decreased across quartiles of tPA activity (<it>p </it>= 0.026). The risk of diabetes with low tPA activity or high PAI-1 activity persisted after adjustment for age and sex but diminished to a non-significant level after further adjustments. The odds ratio of diabetes for high tPA antigen was 10.4 (95% confidence interval 2.7–40) adjusted for age and sex. After further adjustment for diastolic blood pressure, waist circumference, insulin, triglycerides, fasting and post load glucose the odds ratio was 6.5 (1.3–33, <it>p </it>= 0.024).</p> <p>Conclusions</p> <p>Impaired fibrinolysis and endothelial dysfunction are evident in subjects with normal glucose tolerance who later develop diabetes. High tPA antigen is predictive of future diabetes independent from the metabolic syndrome.</p> |
| first_indexed | 2024-04-12T16:11:44Z |
| format | Article |
| id | doaj.art-4a532707507f40b4a75767e11bc84905 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-12T16:11:44Z |
| publishDate | 2003-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-4a532707507f40b4a75767e11bc849052022-12-22T03:25:52ZengBMCCardiovascular Diabetology1475-28402003-12-01211910.1186/1475-2840-2-19High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA StudyJansson Jan-HåkanEliasson Mats CELindahl BerntStegmayr Birgitta<p>Abstract</p> <p>Background</p> <p>Impaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes, associated with components of the metabolic syndrome. There are no data concerning fibrinolysis in subjects with normal glucose tolerance that convert to diabetes.</p> <p>Methods</p> <p>We studied the activities of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) and the levels of tPA antigen (a marker of endothelial dysfunction) in 551 subjects with normal glucose tolerance in 1990 in relation to incident diabetes during nine years of follow-up.</p> <p>Results</p> <p>Subjects with diabetes at follow-up (n = 15) had significantly lower baseline tPA activity and higher PAI-1 activity and tPA antigen than non-converters. The risk of diabetes increased linearly across quartiles of PAI-activity (<it>p </it>= 0.007) and tPA antigen (<it>p </it>< 0.001) and decreased across quartiles of tPA activity (<it>p </it>= 0.026). The risk of diabetes with low tPA activity or high PAI-1 activity persisted after adjustment for age and sex but diminished to a non-significant level after further adjustments. The odds ratio of diabetes for high tPA antigen was 10.4 (95% confidence interval 2.7–40) adjusted for age and sex. After further adjustment for diastolic blood pressure, waist circumference, insulin, triglycerides, fasting and post load glucose the odds ratio was 6.5 (1.3–33, <it>p </it>= 0.024).</p> <p>Conclusions</p> <p>Impaired fibrinolysis and endothelial dysfunction are evident in subjects with normal glucose tolerance who later develop diabetes. High tPA antigen is predictive of future diabetes independent from the metabolic syndrome.</p>http://www.cardiab.com/content/2/1/19 |
| spellingShingle | Jansson Jan-Håkan Eliasson Mats CE Lindahl Bernt Stegmayr Birgitta High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study Cardiovascular Diabetology |
| title | High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study |
| title_full | High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study |
| title_fullStr | High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study |
| title_full_unstemmed | High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study |
| title_short | High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study |
| title_sort | high levels of tissue plasminogen activator tpa antigen precede the development of type 2 diabetes in a longitudinal population study the northern sweden monica study |
| url | http://www.cardiab.com/content/2/1/19 |
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