The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model
The lateral habenula (LHb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. Recently it has been demonstrated that chronic early-life stress results in individual differences in stress vulnerability among roden...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289523000589 |
| _version_ | 1797405398086451200 |
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| author | Miseon Kang Jun-mo Chung Jihyun Noh Jeongyeon Kim |
| author_facet | Miseon Kang Jun-mo Chung Jihyun Noh Jeongyeon Kim |
| author_sort | Miseon Kang |
| collection | DOAJ |
| description | The lateral habenula (LHb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. Recently it has been demonstrated that chronic early-life stress results in individual differences in stress vulnerability among rodents. However, how synaptic function in the LHb varies between susceptibility and resilience to early life stress remains elusive. In this study, we used a maternal separation model to assign animals with different stress vulnerabilities into groups and investigated the synaptic responses in the LHb. Our findings indicate that synaptic long-term depression (LTD) was impaired and extra-synaptic LTD was enhanced in the LHb of the susceptible group. To mimic the synaptic alteration in stress situations, when administered corticosterone, a stress hormone, the intervention appeared to impair synaptic LTD in the LHb of the control group, through the activation of mineralocorticoid receptors (MR). Indeed, there was an up-regulation of MR mRNA observed in the susceptible group. Following there was an up-regulation of both NR2A and NR2B subunits in the LHb. These results indicated that MR and extra-synaptic NMDA receptors in LHb are critically engaged in the susceptibilities to stress. Furthermore, our findings propose potential therapeutic targets for alleviating stress-related symptoms. |
| first_indexed | 2024-03-09T03:09:49Z |
| format | Article |
| id | doaj.art-4a55d1ff095c40ce97aa2b45ea3a8f2a |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-03-09T03:09:49Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-4a55d1ff095c40ce97aa2b45ea3a8f2a2023-12-04T05:22:59ZengElsevierNeurobiology of Stress2352-28952023-11-0127100570The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation modelMiseon Kang0Jun-mo Chung1Jihyun Noh2Jeongyeon Kim3Department of Brain and Cognitive Sciences, Brain Disease Research Institute, Ewha Woman's University, Seoul, South Korea; Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu, South KoreaDepartment of Brain and Cognitive Sciences, Brain Disease Research Institute, Ewha Woman's University, Seoul, South KoreaDepartment of Science Education, College of Education, Dankook University, Yongin, South Korea; Corresponding author.Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu, South Korea; Corresponding author.The lateral habenula (LHb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. Recently it has been demonstrated that chronic early-life stress results in individual differences in stress vulnerability among rodents. However, how synaptic function in the LHb varies between susceptibility and resilience to early life stress remains elusive. In this study, we used a maternal separation model to assign animals with different stress vulnerabilities into groups and investigated the synaptic responses in the LHb. Our findings indicate that synaptic long-term depression (LTD) was impaired and extra-synaptic LTD was enhanced in the LHb of the susceptible group. To mimic the synaptic alteration in stress situations, when administered corticosterone, a stress hormone, the intervention appeared to impair synaptic LTD in the LHb of the control group, through the activation of mineralocorticoid receptors (MR). Indeed, there was an up-regulation of MR mRNA observed in the susceptible group. Following there was an up-regulation of both NR2A and NR2B subunits in the LHb. These results indicated that MR and extra-synaptic NMDA receptors in LHb are critically engaged in the susceptibilities to stress. Furthermore, our findings propose potential therapeutic targets for alleviating stress-related symptoms.http://www.sciencedirect.com/science/article/pii/S2352289523000589Stress vulnerabilityLateral habenulaExtra-synaptic LTDMineralocorticoid receptor |
| spellingShingle | Miseon Kang Jun-mo Chung Jihyun Noh Jeongyeon Kim The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model Neurobiology of Stress Stress vulnerability Lateral habenula Extra-synaptic LTD Mineralocorticoid receptor |
| title | The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| title_full | The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| title_fullStr | The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| title_full_unstemmed | The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| title_short | The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| title_sort | mineralocorticoid receptor and extra synaptic nmda receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model |
| topic | Stress vulnerability Lateral habenula Extra-synaptic LTD Mineralocorticoid receptor |
| url | http://www.sciencedirect.com/science/article/pii/S2352289523000589 |
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