MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO)
Abstract Background PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characteristics of an HD-120 MLC (Varian), simulated using PRIMO, were here com...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-12-01
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| Series: | Radiation Oncology |
| Online Access: | https://doi.org/10.1186/s13014-019-1421-y |
| _version_ | 1831543761838014464 |
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| author | Lucia Paganini Giacomo Reggiori Antonella Stravato Valentina Palumbo Pietro Mancosu Francesca Lobefalo Anna Gaudino Antonella Fogliata Marta Scorsetti Stefano Tomatis |
| author_facet | Lucia Paganini Giacomo Reggiori Antonella Stravato Valentina Palumbo Pietro Mancosu Francesca Lobefalo Anna Gaudino Antonella Fogliata Marta Scorsetti Stefano Tomatis |
| author_sort | Lucia Paganini |
| collection | DOAJ |
| description | Abstract Background PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characteristics of an HD-120 MLC (Varian), simulated using PRIMO, were here compared with measurements, and also with Acuros calculations (in the Eclipse treatment planning system, Varian). Materials and methods A 10 MV FFF beam from a Varian EDGE linac equipped with the HD-120 MLC was used for this work. Initially, the linac head was simulated inside PRIMO, and validated against measurements in a water phantom. Then, a series of different MLC patterns were established to assess the MLC dosimetric characteristics. Those tests included: i) static fields: output factors from MLC shaped fields (2 × 2 to 10 × 10 cm2), alternate open and closed leaf pattern, MLC transmitted dose; ii) dynamic fields: dosimetric leaf gap (DLG) evaluated with sweeping gaps, tongue and groove (TG) effect assessed with profiles across alternate open and closed leaves moving across the field. The doses in the different tests were simulated in PRIMO and then compared with EBT3 film measurements in solid water phantom, as well as with Acuros calculations. Finally, MC in PRIMO and Acuros were compared in some clinical cases, summarizing the clinical complexity in view of a possible use of PRIMO as an independent dose calculation check. Results Static output factor MLC tests showed an agreement between MC calculated and measured OF of 0.5%. The dynamic tests presented DLG values of 0.033 ± 0.003 cm and 0.032 ± 0.006 cm for MC and measurements, respectively. Regarding the TG tests, a general agreement between the dose distributions of 1–2% was achieved, except for the extreme patterns (very small gaps/field sizes and high TG effect) were the agreement was about 4–5%. The analysis of the clinical cases, the Gamma agreement between MC in PRIMO and Acuros dose calculation in Eclipse was of 99.5 ± 0.2% for 3%/2 mm criteria of dose difference/distance to agreement. Conclusions MC simulations in the PRIMO environment were in agreement with measurements for the HD-120 MLC in a 10 MV FFF beam from a Varian EDGE linac. This result allowed to consistently compare clinical cases, showing the possible use of PRIMO as an independent dose calculation check tool. |
| first_indexed | 2024-12-17T00:56:49Z |
| format | Article |
| id | doaj.art-4a57d01071744172bb25790a6c2fdff3 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-17T00:56:49Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-4a57d01071744172bb25790a6c2fdff32022-12-21T22:09:35ZengBMCRadiation Oncology1748-717X2019-12-0114111310.1186/s13014-019-1421-yMLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO)Lucia Paganini0Giacomo Reggiori1Antonella Stravato2Valentina Palumbo3Pietro Mancosu4Francesca Lobefalo5Anna Gaudino6Antonella Fogliata7Marta Scorsetti8Stefano Tomatis9Radiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research CenterAbstract Background PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characteristics of an HD-120 MLC (Varian), simulated using PRIMO, were here compared with measurements, and also with Acuros calculations (in the Eclipse treatment planning system, Varian). Materials and methods A 10 MV FFF beam from a Varian EDGE linac equipped with the HD-120 MLC was used for this work. Initially, the linac head was simulated inside PRIMO, and validated against measurements in a water phantom. Then, a series of different MLC patterns were established to assess the MLC dosimetric characteristics. Those tests included: i) static fields: output factors from MLC shaped fields (2 × 2 to 10 × 10 cm2), alternate open and closed leaf pattern, MLC transmitted dose; ii) dynamic fields: dosimetric leaf gap (DLG) evaluated with sweeping gaps, tongue and groove (TG) effect assessed with profiles across alternate open and closed leaves moving across the field. The doses in the different tests were simulated in PRIMO and then compared with EBT3 film measurements in solid water phantom, as well as with Acuros calculations. Finally, MC in PRIMO and Acuros were compared in some clinical cases, summarizing the clinical complexity in view of a possible use of PRIMO as an independent dose calculation check. Results Static output factor MLC tests showed an agreement between MC calculated and measured OF of 0.5%. The dynamic tests presented DLG values of 0.033 ± 0.003 cm and 0.032 ± 0.006 cm for MC and measurements, respectively. Regarding the TG tests, a general agreement between the dose distributions of 1–2% was achieved, except for the extreme patterns (very small gaps/field sizes and high TG effect) were the agreement was about 4–5%. The analysis of the clinical cases, the Gamma agreement between MC in PRIMO and Acuros dose calculation in Eclipse was of 99.5 ± 0.2% for 3%/2 mm criteria of dose difference/distance to agreement. Conclusions MC simulations in the PRIMO environment were in agreement with measurements for the HD-120 MLC in a 10 MV FFF beam from a Varian EDGE linac. This result allowed to consistently compare clinical cases, showing the possible use of PRIMO as an independent dose calculation check tool.https://doi.org/10.1186/s13014-019-1421-y |
| spellingShingle | Lucia Paganini Giacomo Reggiori Antonella Stravato Valentina Palumbo Pietro Mancosu Francesca Lobefalo Anna Gaudino Antonella Fogliata Marta Scorsetti Stefano Tomatis MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) Radiation Oncology |
| title | MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) |
| title_full | MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) |
| title_fullStr | MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) |
| title_full_unstemmed | MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) |
| title_short | MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO) |
| title_sort | mlc parameters from static fields to vmat plans an evaluation in a rt dedicated mc environment primo |
| url | https://doi.org/10.1186/s13014-019-1421-y |
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