Analytical tools for the characterization of deamidation in monoclonal antibodies

Analytical tools for the characterization of deamidation in monoclonal antibodies

This review focuses on the deamidation of asparagine in monoclonal antibodies, one of the well-known degradation pathways. The importance of close monitoring of deamidation from early developability assessment to in vivo studies is discussed consequentially. The application of chromatographic and el...

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Bibliographic Details
Main Authors:	Baubek Spanov, Natalia Govorukhina, Nico C. van de Merbel, Rainer Bischoff
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Series:	Journal of Chromatography Open
Subjects:	Ion-exchange chromatography Mass spectrometry Monoclonal antibody Bioanalys Deamidation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772391721000256

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