Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review
ObjectiveGenetics and dietary factors play important roles in the development of colorectal cancer (CRC). However, the underlying mechanisms of the interactions between CRC, gene polymorphisms, and dietary fat are unclear. This review study investigated the effects of polymorphisms of arachidonate l...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.865208/full |
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| author | Maryam Gholamalizadeh Nazanin Majidi Shirin Tajaddod Sepideh Abdollahi Seyed Mohammad Poorhosseini Mina Ahmadzadeh Mohammad Naimi Joubani Samaneh Mirzaei Dahka Hanieh Shafaei Mogge Hajiesmaeil Atiyeh Alizadeh Saeid Doaei Anahita Houshiar-Rad |
| author_facet | Maryam Gholamalizadeh Nazanin Majidi Shirin Tajaddod Sepideh Abdollahi Seyed Mohammad Poorhosseini Mina Ahmadzadeh Mohammad Naimi Joubani Samaneh Mirzaei Dahka Hanieh Shafaei Mogge Hajiesmaeil Atiyeh Alizadeh Saeid Doaei Anahita Houshiar-Rad |
| author_sort | Maryam Gholamalizadeh |
| collection | DOAJ |
| description | ObjectiveGenetics and dietary factors play important roles in the development of colorectal cancer (CRC). However, the underlying mechanisms of the interactions between CRC, gene polymorphisms, and dietary fat are unclear. This review study investigated the effects of polymorphisms of arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) genes in the association between CRC and dietary fat.MethodsAll the related papers published from 2000 to 2022 were collected from different databases such as PubMed, Science Direct, Scopus, and Cochran using related keywords such as colorectal cancer, ALOX, COX, polymorphism, and dietary fat. Non-English and unrelated documents were excluded.ResultsSome single-nucleotide polymorphisms (SNPs) in the ALOX and COX genes, such as rs2228065, rs6413416, and rs4986832 in the ALOX gene, and rs689465 in the COX gene may play significant roles in the association between the risk of CRC and dietary fats. SNPs of ALOX and COX genes may influence the effects of dietary fatty acids on the risk of CRC.ConclusionSome polymorphisms of the ALOX and COX genes may have important roles in the effects of dietary fat on the risk of CRC. If future studies confirm these results, dietary recommendations for preventing colorectal cancer may be personalized based on the genotype of the ALOX and COX genes. |
| first_indexed | 2024-12-12T01:25:50Z |
| format | Article |
| id | doaj.art-4a5bf471cc1240d892ddb2c1b04dc043 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T01:25:50Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4a5bf471cc1240d892ddb2c1b04dc0432022-12-22T00:43:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.865208865208Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature ReviewMaryam Gholamalizadeh0Nazanin Majidi1Shirin Tajaddod2Sepideh Abdollahi3Seyed Mohammad Poorhosseini4Mina Ahmadzadeh5Mohammad Naimi Joubani6Samaneh Mirzaei Dahka7Hanieh Shafaei8Mogge Hajiesmaeil9Atiyeh Alizadeh10Saeid Doaei11Anahita Houshiar-Rad12Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Center of Health and Enviroment, School of Health, Guilan University of Medical Sciences, Rasht, IranNursing and Midwifery School, Guilan University of Medical Sciences, Rasht, IranNursing and Midwifery School, Guilan University of Medical Sciences, Rasht, IranDepartment of Biology and Biotechnology ”Charles Darwin”, Sapienza University of Rome, Rome, ItalyDepartment of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran0Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran1Dept. of Nutrition Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranObjectiveGenetics and dietary factors play important roles in the development of colorectal cancer (CRC). However, the underlying mechanisms of the interactions between CRC, gene polymorphisms, and dietary fat are unclear. This review study investigated the effects of polymorphisms of arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) genes in the association between CRC and dietary fat.MethodsAll the related papers published from 2000 to 2022 were collected from different databases such as PubMed, Science Direct, Scopus, and Cochran using related keywords such as colorectal cancer, ALOX, COX, polymorphism, and dietary fat. Non-English and unrelated documents were excluded.ResultsSome single-nucleotide polymorphisms (SNPs) in the ALOX and COX genes, such as rs2228065, rs6413416, and rs4986832 in the ALOX gene, and rs689465 in the COX gene may play significant roles in the association between the risk of CRC and dietary fats. SNPs of ALOX and COX genes may influence the effects of dietary fatty acids on the risk of CRC.ConclusionSome polymorphisms of the ALOX and COX genes may have important roles in the effects of dietary fat on the risk of CRC. If future studies confirm these results, dietary recommendations for preventing colorectal cancer may be personalized based on the genotype of the ALOX and COX genes.https://www.frontiersin.org/articles/10.3389/fonc.2022.865208/fullcolorectal cancerpolymorphismdietary fatlipoxygenasecyclooxygenase |
| spellingShingle | Maryam Gholamalizadeh Nazanin Majidi Shirin Tajaddod Sepideh Abdollahi Seyed Mohammad Poorhosseini Mina Ahmadzadeh Mohammad Naimi Joubani Samaneh Mirzaei Dahka Hanieh Shafaei Mogge Hajiesmaeil Atiyeh Alizadeh Saeid Doaei Anahita Houshiar-Rad Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review Frontiers in Oncology colorectal cancer polymorphism dietary fat lipoxygenase cyclooxygenase |
| title | Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review |
| title_full | Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review |
| title_fullStr | Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review |
| title_full_unstemmed | Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review |
| title_short | Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review |
| title_sort | interactions of colorectal cancer dietary fats and polymorphisms of arachidonate lipoxygenase and cyclooxygenase genes a literature review |
| topic | colorectal cancer polymorphism dietary fat lipoxygenase cyclooxygenase |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.865208/full |
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