Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population
Abstract Insulin resistance (IR) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). IR markers are divided into two types: (1) insulin-based IR marker, homeostatic model assessment of IR (HOMA-IR); and (2) non-insulin-based IR markers, such as triglyceride-gluco...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47269-4 |
| _version_ | 1797453058466119680 |
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| author | Pei Zeng Xiangsheng Cai Xiaozhou Yu Linjing Gong |
| author_facet | Pei Zeng Xiangsheng Cai Xiaozhou Yu Linjing Gong |
| author_sort | Pei Zeng |
| collection | DOAJ |
| description | Abstract Insulin resistance (IR) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). IR markers are divided into two types: (1) insulin-based IR marker, homeostatic model assessment of IR (HOMA-IR); and (2) non-insulin-based IR markers, such as triglyceride-glucose (TyG) index, TyG index with body mass index (TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), and metabolic score for IR (METS-IR). The non-insulin-based IR markers are often associated with lipids. The aim of this study was to analyse the association between IR markers and NAFLD in non-diabetic population. Baseline data of NAFLD and non-NAFLD groups were compared. Logistic regression was used to evaluate the relationship between five IR markers and NAFLD risk. The odds ratios (ORs) and 95% confidence intervals (CIs) of IR markers were calculated. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to evaluate the ability of different IR markers to detect NAFLD. Subgroup analyses were performed in obese and non-obese subgroups. This study found a positive correlation between NAFLD risk and elevation in five IR markers (HOMA-IR, TyG, TyG-BMI, TG/HDL-c, and METS-IR). In non-obese subjects, the AUC of TyG-BMI was larger than that of the other four IR markers to detect NAFLD. The AUC of HOMA-IR was larger than that of the other four IR markers to detect NAFLD in obese subjects. In non-diabetic population, the five IR markers are associated with the risk of NAFLD, including non-obese and obese NAFLD. TyG-BMI and HOMA-IR can be used to detect non-obese and obese NAFLD, respectively, with better detection ability compared with the other IR markers. |
| first_indexed | 2024-03-09T15:17:27Z |
| format | Article |
| id | doaj.art-4a5c6528f95c40ed92e43d607003b9f2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:17:27Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4a5c6528f95c40ed92e43d607003b9f22023-11-26T12:59:25ZengNature PortfolioScientific Reports2045-23222023-11-011311810.1038/s41598-023-47269-4Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic populationPei Zeng0Xiangsheng Cai1Xiaozhou Yu2Linjing Gong3Guangzhou Cadre Health Management CenterGuangzhou Cadre Health Management CenterSchool of Public Health, Sun Yat-Sen UniversityGuangzhou Cadre Health Management CenterAbstract Insulin resistance (IR) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). IR markers are divided into two types: (1) insulin-based IR marker, homeostatic model assessment of IR (HOMA-IR); and (2) non-insulin-based IR markers, such as triglyceride-glucose (TyG) index, TyG index with body mass index (TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), and metabolic score for IR (METS-IR). The non-insulin-based IR markers are often associated with lipids. The aim of this study was to analyse the association between IR markers and NAFLD in non-diabetic population. Baseline data of NAFLD and non-NAFLD groups were compared. Logistic regression was used to evaluate the relationship between five IR markers and NAFLD risk. The odds ratios (ORs) and 95% confidence intervals (CIs) of IR markers were calculated. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to evaluate the ability of different IR markers to detect NAFLD. Subgroup analyses were performed in obese and non-obese subgroups. This study found a positive correlation between NAFLD risk and elevation in five IR markers (HOMA-IR, TyG, TyG-BMI, TG/HDL-c, and METS-IR). In non-obese subjects, the AUC of TyG-BMI was larger than that of the other four IR markers to detect NAFLD. The AUC of HOMA-IR was larger than that of the other four IR markers to detect NAFLD in obese subjects. In non-diabetic population, the five IR markers are associated with the risk of NAFLD, including non-obese and obese NAFLD. TyG-BMI and HOMA-IR can be used to detect non-obese and obese NAFLD, respectively, with better detection ability compared with the other IR markers.https://doi.org/10.1038/s41598-023-47269-4 |
| spellingShingle | Pei Zeng Xiangsheng Cai Xiaozhou Yu Linjing Gong Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population Scientific Reports |
| title | Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population |
| title_full | Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population |
| title_fullStr | Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population |
| title_full_unstemmed | Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population |
| title_short | Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population |
| title_sort | markers of insulin resistance associated with non alcoholic fatty liver disease in non diabetic population |
| url | https://doi.org/10.1038/s41598-023-47269-4 |
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