Capturing a flavivirus pre-fusion intermediate.

Capturing a flavivirus pre-fusion intermediate.

During cell entry of flaviviruses, low endosomal pH triggers the rearrangement of the viral surface glycoproteins to a fusion-active state that allows the release of the infectious RNA into the cytoplasm. In this work, West Nile virus was complexed with Fab fragments of the neutralizing mAb E16 and...

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Bibliographic Details
Main Authors: Bärbel Kaufmann, Paul R Chipman, Heather A Holdaway, Syd Johnson, Daved H Fremont, Richard J Kuhn, Michael S Diamond, Michael G Rossmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2776511?pdf=render

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