Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus
Background/purpose: Oral lichen planus (OLP) is generally considered as an oral potentially malignant disorder (OPMD). Previous studies have shown significantly higher serum carcinoembryonic antigen (CEA), squamous cell carcinoma-antigen (SCC-Ag), and ferritin levels in patients with OPMDs such as o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S199179022300065X |
| _version_ | 1797808393641000960 |
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| author | Yu-Hsueh Wu Chun-Pin Chiang |
| author_facet | Yu-Hsueh Wu Chun-Pin Chiang |
| author_sort | Yu-Hsueh Wu |
| collection | DOAJ |
| description | Background/purpose: Oral lichen planus (OLP) is generally considered as an oral potentially malignant disorder (OPMD). Previous studies have shown significantly higher serum carcinoembryonic antigen (CEA), squamous cell carcinoma-antigen (SCC-Ag), and ferritin levels in patients with OPMDs such as oral submucous fibrosis, oral leukoplakia, oral erythroleukoplakia, or oral verrucous hyperplasia. This study aimed to evaluate whether there were significantly higher serum levels and positive rates of CEA, SCC-Ag, and ferritin in OLP patients than in healthy control subjects. Materials and methods: The serum CEA, SCC-Ag, and ferritin levels in 106 OLP patients and 187 healthy control subjects were measured and compared. Patients with serum CEA level ≥3 ng/mL, SCC-Ag level ≥2 ng/mL, and ferritin level ≥250 ng/mL were scored as serum positive for CEA, SCC-Ag, and ferritin, respectively. Results: This study found significantly higher mean serum CEA and ferritin levels in 106 OLP patients than in 187 healthy control subjects. Moreover, 106 OLP patients had significantly higher serum positive rates of CEA (12.3%) and ferritin (33.0%) than 187 healthy control subjects. Although the mean serum SCC-Ag level was higher in 106 OLP patients than in 187 healthy control subjects, the difference was not statistically significant. Of the 106 OLP patients, 39 (36.8%), 5 (4.7%), and 0 (0.0%) had serum positivities of one, two, or three tumor biomarkers including CEA, SCC-Ag, and ferritin, respectively. Conclusion: Our findings indicate significantly higher serum levels and positive rates of CEA and ferritin in OLP patients than in healthy control subjects. |
| first_indexed | 2024-03-13T06:36:52Z |
| format | Article |
| id | doaj.art-4a5ef7a9126f4b779585831c25c1263e |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-03-13T06:36:52Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-4a5ef7a9126f4b779585831c25c1263e2023-06-09T04:27:35ZengElsevierJournal of Dental Sciences1991-79022023-07-0118312881294Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planusYu-Hsueh Wu0Chun-Pin Chiang1Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Oral Medicine, School of Dentistry, National Cheng Kung University, Tainan, TaiwanDepartment of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan.Background/purpose: Oral lichen planus (OLP) is generally considered as an oral potentially malignant disorder (OPMD). Previous studies have shown significantly higher serum carcinoembryonic antigen (CEA), squamous cell carcinoma-antigen (SCC-Ag), and ferritin levels in patients with OPMDs such as oral submucous fibrosis, oral leukoplakia, oral erythroleukoplakia, or oral verrucous hyperplasia. This study aimed to evaluate whether there were significantly higher serum levels and positive rates of CEA, SCC-Ag, and ferritin in OLP patients than in healthy control subjects. Materials and methods: The serum CEA, SCC-Ag, and ferritin levels in 106 OLP patients and 187 healthy control subjects were measured and compared. Patients with serum CEA level ≥3 ng/mL, SCC-Ag level ≥2 ng/mL, and ferritin level ≥250 ng/mL were scored as serum positive for CEA, SCC-Ag, and ferritin, respectively. Results: This study found significantly higher mean serum CEA and ferritin levels in 106 OLP patients than in 187 healthy control subjects. Moreover, 106 OLP patients had significantly higher serum positive rates of CEA (12.3%) and ferritin (33.0%) than 187 healthy control subjects. Although the mean serum SCC-Ag level was higher in 106 OLP patients than in 187 healthy control subjects, the difference was not statistically significant. Of the 106 OLP patients, 39 (36.8%), 5 (4.7%), and 0 (0.0%) had serum positivities of one, two, or three tumor biomarkers including CEA, SCC-Ag, and ferritin, respectively. Conclusion: Our findings indicate significantly higher serum levels and positive rates of CEA and ferritin in OLP patients than in healthy control subjects.http://www.sciencedirect.com/science/article/pii/S199179022300065XOral lichen planusCarcinoembryonic antigenSquamous cell carcinoma antigenFerritinBiomarker |
| spellingShingle | Yu-Hsueh Wu Chun-Pin Chiang Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus Journal of Dental Sciences Oral lichen planus Carcinoembryonic antigen Squamous cell carcinoma antigen Ferritin Biomarker |
| title | Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| title_full | Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| title_fullStr | Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| title_full_unstemmed | Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| title_short | Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| title_sort | significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus |
| topic | Oral lichen planus Carcinoembryonic antigen Squamous cell carcinoma antigen Ferritin Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S199179022300065X |
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