The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth dependi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02895/full |
| _version_ | 1818022029876527104 |
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| author | Laura Ducimetière Marijne Vermeer Sonia Tugues |
| author_facet | Laura Ducimetière Marijne Vermeer Sonia Tugues |
| author_sort | Laura Ducimetière |
| collection | DOAJ |
| description | The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth depending on the environmental conditions. The differential effects of ILCs on tumor outcome have been attributed to the high degree of heterogeneity and plasticity within the ILC family members. However, it is now becoming clear that ILCs responses are shaped by their dynamic crosstalk with the different components of the tumor microenvironment (TME). In this review, we will give insights into the molecular and cellular players of the ILCs-TME interactions and we will discuss how we can use this knowledge to successfully harness the activity of ILCs for anticancer therapies. |
| first_indexed | 2024-04-14T08:27:00Z |
| format | Article |
| id | doaj.art-4a600d1232df42e386a07f583f7129e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T08:27:00Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4a600d1232df42e386a07f583f7129e82022-12-22T02:04:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02895505927The Interplay Between Innate Lymphoid Cells and the Tumor MicroenvironmentLaura DucimetièreMarijne VermeerSonia TuguesThe multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth depending on the environmental conditions. The differential effects of ILCs on tumor outcome have been attributed to the high degree of heterogeneity and plasticity within the ILC family members. However, it is now becoming clear that ILCs responses are shaped by their dynamic crosstalk with the different components of the tumor microenvironment (TME). In this review, we will give insights into the molecular and cellular players of the ILCs-TME interactions and we will discuss how we can use this knowledge to successfully harness the activity of ILCs for anticancer therapies.https://www.frontiersin.org/article/10.3389/fimmu.2019.02895/fullinnate lymphoid cellstumor microenvironmentcrosstalkimmune evasionimmune modulation |
| spellingShingle | Laura Ducimetière Marijne Vermeer Sonia Tugues The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment Frontiers in Immunology innate lymphoid cells tumor microenvironment crosstalk immune evasion immune modulation |
| title | The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment |
| title_full | The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment |
| title_fullStr | The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment |
| title_full_unstemmed | The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment |
| title_short | The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment |
| title_sort | interplay between innate lymphoid cells and the tumor microenvironment |
| topic | innate lymphoid cells tumor microenvironment crosstalk immune evasion immune modulation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02895/full |
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