Intratumor and Intertumor Heterogeneity in Melanoma
Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate fro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-12-01
|
| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523317302759 |
| _version_ | 1828325598928306176 |
|---|---|
| author | Tomasz M. Grzywa Wiktor Paskal Paweł K. Włodarski |
| author_facet | Tomasz M. Grzywa Wiktor Paskal Paweł K. Włodarski |
| author_sort | Tomasz M. Grzywa |
| collection | DOAJ |
| description | Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate from different subclones of primary lesion. Such component of the neoplasm biology is termed intertumor and intratumor heterogeneity. These levels of tumor heterogeneity hinder accurate diagnosis and effective treatment. The increasing number of research on the topic reflects the need for understanding limitation or failure of contemporary therapies. Majority of analyses concentrate on mutations in cancer-related genes. Novel high-throughput techniques reveal even higher degree of variations within a lesion. Consolidation of theories and researches indicates new routes for treatment options such as targets for immunotherapy. The demand for personalized approach in melanoma treatment requires extensive knowledge on intratumor and intertumor heterogeneity on the level of genome, transcriptome/proteome, and epigenome. Thus, achievements in exploration of melanoma variety are described in details. Particularly, the issue of tumor heterogeneity or homogeneity given BRAF mutations is discussed. |
| first_indexed | 2024-04-13T19:25:26Z |
| format | Article |
| id | doaj.art-4a61e55ce30d419487d011dc1f21bdec |
| institution | Directory Open Access Journal |
| issn | 1936-5233 1944-7124 |
| language | English |
| last_indexed | 2024-04-13T19:25:26Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-4a61e55ce30d419487d011dc1f21bdec2022-12-22T02:33:23ZengElsevierTranslational Oncology1936-52331944-71242017-12-0110695697510.1016/j.tranon.2017.09.007Intratumor and Intertumor Heterogeneity in MelanomaTomasz M. GrzywaWiktor PaskalPaweł K. WłodarskiMelanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate from different subclones of primary lesion. Such component of the neoplasm biology is termed intertumor and intratumor heterogeneity. These levels of tumor heterogeneity hinder accurate diagnosis and effective treatment. The increasing number of research on the topic reflects the need for understanding limitation or failure of contemporary therapies. Majority of analyses concentrate on mutations in cancer-related genes. Novel high-throughput techniques reveal even higher degree of variations within a lesion. Consolidation of theories and researches indicates new routes for treatment options such as targets for immunotherapy. The demand for personalized approach in melanoma treatment requires extensive knowledge on intratumor and intertumor heterogeneity on the level of genome, transcriptome/proteome, and epigenome. Thus, achievements in exploration of melanoma variety are described in details. Particularly, the issue of tumor heterogeneity or homogeneity given BRAF mutations is discussed.http://www.sciencedirect.com/science/article/pii/S1936523317302759 |
| spellingShingle | Tomasz M. Grzywa Wiktor Paskal Paweł K. Włodarski Intratumor and Intertumor Heterogeneity in Melanoma Translational Oncology |
| title | Intratumor and Intertumor Heterogeneity in Melanoma |
| title_full | Intratumor and Intertumor Heterogeneity in Melanoma |
| title_fullStr | Intratumor and Intertumor Heterogeneity in Melanoma |
| title_full_unstemmed | Intratumor and Intertumor Heterogeneity in Melanoma |
| title_short | Intratumor and Intertumor Heterogeneity in Melanoma |
| title_sort | intratumor and intertumor heterogeneity in melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S1936523317302759 |
| work_keys_str_mv | AT tomaszmgrzywa intratumorandintertumorheterogeneityinmelanoma AT wiktorpaskal intratumorandintertumorheterogeneityinmelanoma AT pawełkwłodarski intratumorandintertumorheterogeneityinmelanoma |