Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration—A New Potential Drug in Sepsis Therapy?

Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration—A New Potential Drug in Sepsis Therapy?

Sepsis is a life-threatening condition caused by the dysregulated host response to infection. Novel therapeutic options are urgently needed and aquaporin inhibitors could suffice as aquaporin 5 (<i>Aqp5</i>) knockdown provided enhanced sepsis survival in a murine sepsis model. Potential...

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Bibliographic Details
Main Authors: Katharina Rump, Björn Koos, Dominik Ziehe, Patrick Thon, Tim Rahmel, Lars Palmowski, Britta Marko, Alexander Wolf, Andrea Witowski, Zainab Bazzi, Maha Bazzi, Jennifer Orlowski, Michael Adamzik, Lars Bergmann, Matthias Unterberg
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
aquaporins
<i>AQP5</i>
sepsis
sulfonamides
methazolamide
furosemide
Online Access:https://www.mdpi.com/1422-0067/25/1/610

Internet

https://www.mdpi.com/1422-0067/25/1/610

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