Prebiotic role of softwood hemicellulose in healthy mice model
We have analyzed the prebiotic effect of softwood hemicelluloses on specific bacterial species in vitro and on microbiota diversity and metabolism in healthy mice in vivo. The ethanol-precipitated glycans from the softwood hemicellulose autohydrolysate were able to stimulate in vitro the growth of B...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619306127 |
| _version_ | 1819291927905828864 |
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| author | Vivien Deloule Claire Boisset Dalil Hannani Antonia Suau Audrey Le Gouellec Jadwiga Chroboczek Cyrille Botté Yoshiki Yamaryo-Botté Christine Chirat Bertrand Toussaint |
| author_facet | Vivien Deloule Claire Boisset Dalil Hannani Antonia Suau Audrey Le Gouellec Jadwiga Chroboczek Cyrille Botté Yoshiki Yamaryo-Botté Christine Chirat Bertrand Toussaint |
| author_sort | Vivien Deloule |
| collection | DOAJ |
| description | We have analyzed the prebiotic effect of softwood hemicelluloses on specific bacterial species in vitro and on microbiota diversity and metabolism in healthy mice in vivo. The ethanol-precipitated glycans from the softwood hemicellulose autohydrolysate were able to stimulate in vitro the growth of Bifidobacterium adolescentis, but to a much lesser extent than that of adherent-invasive E. coli. B. adolescentis was the best producer of SCFA. When mice were fed with the ethanol precipitate fraction, the relative abundance of Bacteroidetes increased while that of Proteobacteria diminished, suggesting change towards a less obesogenic microbiome. Following treatment, lipid analysis showed a decrease in cholesterol, bile acids and free fatty acids, indicating a potential cardioprotection role. Furthermore, analysis of fermentation metabolites revealed an increase in metabolites important for immune health and well-being. Our results highlight the value of hemicelluloses as a potential source of prebiotics supporting both a healthy digestive tract and immune system. |
| first_indexed | 2024-12-24T03:46:25Z |
| format | Article |
| id | doaj.art-4a6450693d0f435c9984da9a1a7fa43b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:46:25Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4a6450693d0f435c9984da9a1a7fa43b2022-12-21T17:16:41ZengElsevierJournal of Functional Foods1756-46462020-01-0164103688Prebiotic role of softwood hemicellulose in healthy mice modelVivien Deloule0Claire Boisset1Dalil Hannani2Antonia Suau3Audrey Le Gouellec4Jadwiga Chroboczek5Cyrille Botté6Yoshiki Yamaryo-Botté7Christine Chirat8Bertrand Toussaint9Univ. Grenoble Alpes, CNRS, Grenoble INP*, LGP2, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS - CERMAV, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, 38000 Grenoble, France; Department of Chemistry, Life and Health Sciences, Conservatoire National des Arts et Métiers, Paris, FranceUniv. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, 38000 Grenoble, France; Institut de Biologie, CHU Grenoble Alpes, FranceUniv. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, 38000 Grenoble, FranceUniv. Grenoble Alpes, Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, 38000 Grenoble, FranceUniv. Grenoble Alpes, Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, Grenoble INP*, LGP2, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, CHU Grenoble Alpes, Grenoble INP*, TIMC-IMAG, 38000 Grenoble, France; Institut de Biologie, CHU Grenoble Alpes, France; Corresponding author at: Institut de Biologie, CHU-Grenoble Alpes, CS10217, 38043 Grenoble Cedex, France.We have analyzed the prebiotic effect of softwood hemicelluloses on specific bacterial species in vitro and on microbiota diversity and metabolism in healthy mice in vivo. The ethanol-precipitated glycans from the softwood hemicellulose autohydrolysate were able to stimulate in vitro the growth of Bifidobacterium adolescentis, but to a much lesser extent than that of adherent-invasive E. coli. B. adolescentis was the best producer of SCFA. When mice were fed with the ethanol precipitate fraction, the relative abundance of Bacteroidetes increased while that of Proteobacteria diminished, suggesting change towards a less obesogenic microbiome. Following treatment, lipid analysis showed a decrease in cholesterol, bile acids and free fatty acids, indicating a potential cardioprotection role. Furthermore, analysis of fermentation metabolites revealed an increase in metabolites important for immune health and well-being. Our results highlight the value of hemicelluloses as a potential source of prebiotics supporting both a healthy digestive tract and immune system.http://www.sciencedirect.com/science/article/pii/S1756464619306127Softwood hemicellulosesPrebioticsHealthy mice modelMicrobiota metabolites |
| spellingShingle | Vivien Deloule Claire Boisset Dalil Hannani Antonia Suau Audrey Le Gouellec Jadwiga Chroboczek Cyrille Botté Yoshiki Yamaryo-Botté Christine Chirat Bertrand Toussaint Prebiotic role of softwood hemicellulose in healthy mice model Journal of Functional Foods Softwood hemicelluloses Prebiotics Healthy mice model Microbiota metabolites |
| title | Prebiotic role of softwood hemicellulose in healthy mice model |
| title_full | Prebiotic role of softwood hemicellulose in healthy mice model |
| title_fullStr | Prebiotic role of softwood hemicellulose in healthy mice model |
| title_full_unstemmed | Prebiotic role of softwood hemicellulose in healthy mice model |
| title_short | Prebiotic role of softwood hemicellulose in healthy mice model |
| title_sort | prebiotic role of softwood hemicellulose in healthy mice model |
| topic | Softwood hemicelluloses Prebiotics Healthy mice model Microbiota metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619306127 |
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