Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide
There are a few reports in the literature implicating them in causing fixed drug eruption, the piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas a piperazine ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared a piperazine ring but also shar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12275 |
| _version_ | 1797328978556485632 |
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| author | Mizuki Terada Shujiro Hayashi Maki Okamoto Ken Igawa |
| author_facet | Mizuki Terada Shujiro Hayashi Maki Okamoto Ken Igawa |
| author_sort | Mizuki Terada |
| collection | DOAJ |
| description | There are a few reports in the literature implicating them in causing fixed drug eruption, the piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas a piperazine ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared a piperazine ring but also shared two benzene rings via a methine group (=CH–). It was suspected that this shared structural group became an antigenic determinant and resulted in cross‐reactivity. Such a unique case has not been reported before. |
| first_indexed | 2024-03-08T06:58:42Z |
| format | Article |
| id | doaj.art-4a654925b8c84aa9adea0d87842e9354 |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T06:58:42Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-4a654925b8c84aa9adea0d87842e93542024-02-03T06:18:33ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932023-04-0162596010.1002/cia2.12275Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomideMizuki Terada0Shujiro Hayashi1Maki Okamoto2Ken Igawa3Department of Dermatology Dokkyo Medical University Mibu JapanDepartment of Dermatology Dokkyo Medical University Mibu JapanDepartment of Dermatology Dokkyo Medical University Mibu JapanDepartment of Dermatology Dokkyo Medical University Mibu JapanThere are a few reports in the literature implicating them in causing fixed drug eruption, the piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas a piperazine ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared a piperazine ring but also shared two benzene rings via a methine group (=CH–). It was suspected that this shared structural group became an antigenic determinant and resulted in cross‐reactivity. Such a unique case has not been reported before.https://doi.org/10.1002/cia2.12275adverse drug eruptionspharmacology and skin‐related toxicology |
| spellingShingle | Mizuki Terada Shujiro Hayashi Maki Okamoto Ken Igawa Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide Journal of Cutaneous Immunology and Allergy adverse drug eruptions pharmacology and skin‐related toxicology |
| title | Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide |
| title_full | Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide |
| title_fullStr | Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide |
| title_full_unstemmed | Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide |
| title_short | Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide |
| title_sort | hydroxyzine induced fixed drug eruption and cross reaction with oxatomide |
| topic | adverse drug eruptions pharmacology and skin‐related toxicology |
| url | https://doi.org/10.1002/cia2.12275 |
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