Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry
Introduction Management controversy and clinical equipoise exist in treatments of long bone fractures and traumatic hip dislocation in paediatric patients due to the lack of high-quality clinical evidence. This protocol describes the effort of a large prospective global multicentre cohort study (reg...
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/3/e079836.full |
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| author | Alexander Joeris Kishore Mulpuri Bryn O Zomar L Johnson S K Gupta D Little K Mulpuri P Schmittenbecher Maio Chen Emily K Schaeffer ADB Buunaaim S Imran Buckari M Ajith Kumar A Bosak Versic A Konstantopoulou I Aguado Maestro M Stitzman Wengrowicz S Carsen U Narayanan R El-Hawary M J Malaret Baldo M Sepulveda |
| author_facet | Alexander Joeris Kishore Mulpuri Bryn O Zomar L Johnson S K Gupta D Little K Mulpuri P Schmittenbecher Maio Chen Emily K Schaeffer ADB Buunaaim S Imran Buckari M Ajith Kumar A Bosak Versic A Konstantopoulou I Aguado Maestro M Stitzman Wengrowicz S Carsen U Narayanan R El-Hawary M J Malaret Baldo M Sepulveda |
| collection | DOAJ |
| description | Introduction Management controversy and clinical equipoise exist in treatments of long bone fractures and traumatic hip dislocation in paediatric patients due to the lack of high-quality clinical evidence. This protocol describes the effort of a large prospective global multicentre cohort study (registry) aiming at providing quality data to assist evidence-based treatment decision-making.Methods and analysis Eligible paediatric patients (N=750–1000) with open physes suffering from proximal humerus fractures, distal humerus fractures, proximal radius fractures, forearm shaft fractures, traumatic hip dislocations, femoral neck fractures or tibial shaft fractures will be recruited over a period of 24–36 months. Hospitalisation and treatment details (including materials and implants) will be captured in a cloud-based, searchable database. Outcome measures include radiographic assessments, clinical outcomes (such as range of motion, limb length discrepancies and implant removal), patient-reported outcomes (Patient Reported Outcomes Of Fracture, Patient-Reported Outcomes Measurement Information System (PROMIS) and EuroQol-5D (EQ-5D-Y)) and adverse events.Aside from descriptive statistics on patient demographics, baseline characteristics, types of fractures and adverse event rates, research questions will be formulated based on data availability and quality. A statistical analysis plan will be prepared before the statistical analysis.Ethics and dissemination Ethics approval will be obtained before patients are enrolled at each participating site. Patient enrolment will follow an informed consent process approved by the responsible ethics committee. Peer-reviewed publication is planned to disseminate the study results.Trial registration number NCT04207892. |
| first_indexed | 2024-04-25T01:24:33Z |
| format | Article |
| id | doaj.art-4a664434e01f40d2b149a96861a5e892 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-25T01:24:33Z |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj.art-4a664434e01f40d2b149a96861a5e8922024-03-09T04:00:09ZengBMJ Publishing GroupBMJ Open2044-60552024-03-0114310.1136/bmjopen-2023-079836Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry Alexander Joeris0Kishore Mulpuri1Bryn O Zomar2L Johnson3S K Gupta4D Little5K Mulpuri6P SchmittenbecherMaio Chen7Emily K Schaeffer8ADB BuunaaimS Imran BuckariM Ajith KumarA Bosak VersicA KonstantopoulouI Aguado MaestroM Stitzman WengrowiczS CarsenU NarayananR El-HawaryM J Malaret BaldoM SepulvedaAOCID, AO Foundation, Dübendorf, Switzerland4 Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada1 Health and Rehabilitation Sciences, Western University Faculty of Health Sciences, London, Ontario, Canada4Director of Medical Education and Consultant in Infectious Diseases, North Manchester General HospitalDr R P Centre for Ophthalmic Sciences, AIIMS, Ansari Nagat, New Delhi, India1Royal United Hospital, Bath, UKDepartment of Orthopaedic Surgery, Women’s and Children’s Hospital, AdelaideAO Innovation Translation Center, AO Foundation, Davos, SwitzerlandDepartment of Orthopaedic Surgery, BC Children’s Hospital, Vancouver, British Columbia, CanadaIntroduction Management controversy and clinical equipoise exist in treatments of long bone fractures and traumatic hip dislocation in paediatric patients due to the lack of high-quality clinical evidence. This protocol describes the effort of a large prospective global multicentre cohort study (registry) aiming at providing quality data to assist evidence-based treatment decision-making.Methods and analysis Eligible paediatric patients (N=750–1000) with open physes suffering from proximal humerus fractures, distal humerus fractures, proximal radius fractures, forearm shaft fractures, traumatic hip dislocations, femoral neck fractures or tibial shaft fractures will be recruited over a period of 24–36 months. Hospitalisation and treatment details (including materials and implants) will be captured in a cloud-based, searchable database. Outcome measures include radiographic assessments, clinical outcomes (such as range of motion, limb length discrepancies and implant removal), patient-reported outcomes (Patient Reported Outcomes Of Fracture, Patient-Reported Outcomes Measurement Information System (PROMIS) and EuroQol-5D (EQ-5D-Y)) and adverse events.Aside from descriptive statistics on patient demographics, baseline characteristics, types of fractures and adverse event rates, research questions will be formulated based on data availability and quality. A statistical analysis plan will be prepared before the statistical analysis.Ethics and dissemination Ethics approval will be obtained before patients are enrolled at each participating site. Patient enrolment will follow an informed consent process approved by the responsible ethics committee. Peer-reviewed publication is planned to disseminate the study results.Trial registration number NCT04207892.https://bmjopen.bmj.com/content/14/3/e079836.full |
| spellingShingle | Alexander Joeris Kishore Mulpuri Bryn O Zomar L Johnson S K Gupta D Little K Mulpuri P Schmittenbecher Maio Chen Emily K Schaeffer ADB Buunaaim S Imran Buckari M Ajith Kumar A Bosak Versic A Konstantopoulou I Aguado Maestro M Stitzman Wengrowicz S Carsen U Narayanan R El-Hawary M J Malaret Baldo M Sepulveda Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry BMJ Open |
| title | Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry |
| title_full | Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry |
| title_fullStr | Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry |
| title_full_unstemmed | Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry |
| title_short | Management of long bone fractures and traumatic hip dislocations in paediatric patients: study protocol for a prospective global multicentre observational cohort registry |
| title_sort | management of long bone fractures and traumatic hip dislocations in paediatric patients study protocol for a prospective global multicentre observational cohort registry |
| url | https://bmjopen.bmj.com/content/14/3/e079836.full |
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