Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses
Older horses and those prone to obesity may be at a higher risk for inflammation than younger and leaner counterparts. Previous research indicated a postprandial elevation in plasma concentrations of interleukin-1β (IL-1β), a pro-inflammatory cytokine, after consuming 1.2 g of non-structural carbohy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/12/3362 |
| _version_ | 1797506932137787392 |
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| author | Jessica Suagee-Bedore Nichola Shost Christian Miller Luis Grado Jeremy Bechelli |
| author_facet | Jessica Suagee-Bedore Nichola Shost Christian Miller Luis Grado Jeremy Bechelli |
| author_sort | Jessica Suagee-Bedore |
| collection | DOAJ |
| description | Older horses and those prone to obesity may be at a higher risk for inflammation than younger and leaner counterparts. Previous research indicated a postprandial elevation in plasma concentrations of interleukin-1β (IL-1β), a pro-inflammatory cytokine, after consuming 1.2 g of non-structural carbohydrates/kilogram of body weight. However, these studies utilized horses of mixed age and body condition. The current study evaluated post-prandial IL-1β concentrations in horses specifically comparing lean to over-conditioned and middle aged to older. Our results suggest that at least two weeks of daily consumption of a high non-structural carbohydrate diet is required to induce a post-prandial increase in IL-1β concentrations in younger and leaner horses. In opposition to this, older and over-conditioned horses experience plasma increased on the first day of feeding and thereafter. Feeding management practices of older and over-conditioned individuals should emphasize lower non-structural carbohydrate intakes and further research should elucidate mechanisms of IL-1β activation. |
| first_indexed | 2024-03-10T04:40:25Z |
| format | Article |
| id | doaj.art-4a6a4e3da4594d81942f680baac94284 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T04:40:25Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-4a6a4e3da4594d81942f680baac942842023-11-23T03:25:44ZengMDPI AGAnimals2076-26152021-11-011112336210.3390/ani11123362Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in HorsesJessica Suagee-Bedore0Nichola Shost1Christian Miller2Luis Grado3Jeremy Bechelli4School of Agricultural Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USASchool of Agricultural Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USADepartment of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USADepartment of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USADepartment of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USAOlder horses and those prone to obesity may be at a higher risk for inflammation than younger and leaner counterparts. Previous research indicated a postprandial elevation in plasma concentrations of interleukin-1β (IL-1β), a pro-inflammatory cytokine, after consuming 1.2 g of non-structural carbohydrates/kilogram of body weight. However, these studies utilized horses of mixed age and body condition. The current study evaluated post-prandial IL-1β concentrations in horses specifically comparing lean to over-conditioned and middle aged to older. Our results suggest that at least two weeks of daily consumption of a high non-structural carbohydrate diet is required to induce a post-prandial increase in IL-1β concentrations in younger and leaner horses. In opposition to this, older and over-conditioned horses experience plasma increased on the first day of feeding and thereafter. Feeding management practices of older and over-conditioned individuals should emphasize lower non-structural carbohydrate intakes and further research should elucidate mechanisms of IL-1β activation.https://www.mdpi.com/2076-2615/11/12/3362equineinflammasomeinterleukin-1βnon-structural carbohydrates |
| spellingShingle | Jessica Suagee-Bedore Nichola Shost Christian Miller Luis Grado Jeremy Bechelli Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses Animals equine inflammasome interleukin-1β non-structural carbohydrates |
| title | Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses |
| title_full | Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses |
| title_fullStr | Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses |
| title_full_unstemmed | Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses |
| title_short | Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses |
| title_sort | age and body condition influence the post prandial interleukin 1β response to a high starch meal in horses |
| topic | equine inflammasome interleukin-1β non-structural carbohydrates |
| url | https://www.mdpi.com/2076-2615/11/12/3362 |
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