Multifocality related factors in papillary thyroid carcinoma
Summary: Background: Papillary thyroid carcinoma (PTC) is the main type of the well-differentiated thyroid carcinomas. Multifocality is regarded as a poor prognostic factor for PTC. Methods: Documents of 777 patients who underwent thyroidectomy were reviewed retrospectively. A total of 305 PTC pati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958418302720 |
| _version_ | 1811285549842956288 |
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| author | Emine Ozlem Gur Serkan Karaisli Selda Haciyanli Erdinc Kamer Hudai Genc Kemal Atahan Mehmet Haciyanli |
| author_facet | Emine Ozlem Gur Serkan Karaisli Selda Haciyanli Erdinc Kamer Hudai Genc Kemal Atahan Mehmet Haciyanli |
| author_sort | Emine Ozlem Gur |
| collection | DOAJ |
| description | Summary: Background: Papillary thyroid carcinoma (PTC) is the main type of the well-differentiated thyroid carcinomas. Multifocality is regarded as a poor prognostic factor for PTC. Methods: Documents of 777 patients who underwent thyroidectomy were reviewed retrospectively. A total of 305 PTC patients were included. Patients with multifocal PTC were included in Group 1, and patients with unifocal PTC were included in Group 2. Results: There were 165 patients (54.0%) in Group 1 and 140 patients (46%) in Group 2. The pathological mixed variant of PTC was significantly higher in Group 1 (p = 0,005). Lymph node metastasis (LNM) was detected at 9.6% and 3.5% in Group 1 and Group 2, respectively (p = 0,028). Micro PTC rates were 28.4% and 40.7% in Group 1 and Group 2, respectively (p = 0,017). Tumor size and pathologically mixed-type and fine-needle aspiration biopsy (FNAB) results were significantly different between multifocal and unifocal Micro PTC (p < 0.05). Conclusions: Multifocality is more frequent in patients with tumors ≥1 cm and mixed-type tumors. LNM is found more often in multifocal tumors. The presence of micropapillary tumors can be predicted preoperatively by ultrasound-guided FNAB. Mixed-type pathology is also a predictive factor for multifocality. Keywords: Thyroid, Papillary thyroid cancer, Multifocal, Micropapillary thyroid cancer |
| first_indexed | 2024-04-13T02:46:45Z |
| format | Article |
| id | doaj.art-4a6c20e361c24525be009f4c7e393322 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-13T02:46:45Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-4a6c20e361c24525be009f4c7e3933222022-12-22T03:06:00ZengElsevierAsian Journal of Surgery1015-95842019-01-01421297302Multifocality related factors in papillary thyroid carcinomaEmine Ozlem Gur0Serkan Karaisli1Selda Haciyanli2Erdinc Kamer3Hudai Genc4Kemal Atahan5Mehmet Haciyanli6Corresponding author. Fax: +90 232 243 1530.; Department of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeyDepartment of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, TurkeySummary: Background: Papillary thyroid carcinoma (PTC) is the main type of the well-differentiated thyroid carcinomas. Multifocality is regarded as a poor prognostic factor for PTC. Methods: Documents of 777 patients who underwent thyroidectomy were reviewed retrospectively. A total of 305 PTC patients were included. Patients with multifocal PTC were included in Group 1, and patients with unifocal PTC were included in Group 2. Results: There were 165 patients (54.0%) in Group 1 and 140 patients (46%) in Group 2. The pathological mixed variant of PTC was significantly higher in Group 1 (p = 0,005). Lymph node metastasis (LNM) was detected at 9.6% and 3.5% in Group 1 and Group 2, respectively (p = 0,028). Micro PTC rates were 28.4% and 40.7% in Group 1 and Group 2, respectively (p = 0,017). Tumor size and pathologically mixed-type and fine-needle aspiration biopsy (FNAB) results were significantly different between multifocal and unifocal Micro PTC (p < 0.05). Conclusions: Multifocality is more frequent in patients with tumors ≥1 cm and mixed-type tumors. LNM is found more often in multifocal tumors. The presence of micropapillary tumors can be predicted preoperatively by ultrasound-guided FNAB. Mixed-type pathology is also a predictive factor for multifocality. Keywords: Thyroid, Papillary thyroid cancer, Multifocal, Micropapillary thyroid cancerhttp://www.sciencedirect.com/science/article/pii/S1015958418302720 |
| spellingShingle | Emine Ozlem Gur Serkan Karaisli Selda Haciyanli Erdinc Kamer Hudai Genc Kemal Atahan Mehmet Haciyanli Multifocality related factors in papillary thyroid carcinoma Asian Journal of Surgery |
| title | Multifocality related factors in papillary thyroid carcinoma |
| title_full | Multifocality related factors in papillary thyroid carcinoma |
| title_fullStr | Multifocality related factors in papillary thyroid carcinoma |
| title_full_unstemmed | Multifocality related factors in papillary thyroid carcinoma |
| title_short | Multifocality related factors in papillary thyroid carcinoma |
| title_sort | multifocality related factors in papillary thyroid carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1015958418302720 |
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