Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies
Background: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-an...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.946554/full |
| _version_ | 1818498779510210560 |
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| author | Shuai Wang Sean X. Luo Jing Jie Dan Li Han Liu Lei Song |
| author_facet | Shuai Wang Sean X. Luo Jing Jie Dan Li Han Liu Lei Song |
| author_sort | Shuai Wang |
| collection | DOAJ |
| description | Background: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-analysis, the therapeutic efficiency of terpenoid administration on the lung wet-to-dry weight ratio in rats was investigated.Methods: Using the Cochrane Library, Embase, and PubMed databases, a comprehensive literature search for studies evaluating the therapeutic efficacy of terpenoids on ALI in rats was conducted. The lung wet-to-dry weight ratio was extracted as the main outcome. The quality of the included studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation’s risk of bias tool.Results: In total, 16 studies were included in this meta-analysis. In general, terpenoids significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle (p = 0.0002; standardized mean difference (SMD): −0.16; 95% confidence interval (CI): −0.24, −0.08). Subgroup analysis revealed that low dose (≤10 μmol/kg) (p < 0.0001; SMD: −0.68; 95% CI: −1.02, −0.34), intraperitoneal injection (p = 0.0002; SMD: −0.43; 95% CI: −0.66, −0.20), diterpenoid (p = 0.004; SMD: −0.13; 95% CI: −0.23, −0.04), and triterpenoid (p = 0.04; SMD: −0.28; 95% CI: −0.54, −0.01) significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle.Conclusion: A low dose of diterpenoid and triterpenoid administered intraperitoneally is effective in alleviating ALI. This systematic review and meta-analysis provides a valuable mirror for clinical research aiming at the advancement of terpenoids for preventive and therapeutic use.Systematic Review Registration: CRD42022326779 |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T20:20:15Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-4a6c3008d56247f0a7f99798eb9035d02022-12-22T01:35:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.946554946554Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studiesShuai Wang0Sean X. Luo1Jing Jie2Dan Li3Han Liu4Lei Song5Department of Vascular Surgery, General Surgery Center, The First Hospital of Jilin University, Chasngchun, JL, ChinaDepartment of Vascular Surgery, General Surgery Center, The First Hospital of Jilin University, Chasngchun, JL, ChinaCenter for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Department of Respiratory Medicine, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, ChinaCenter for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Department of Respiratory Medicine, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, ChinaCenter for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Department of Respiratory Medicine, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, ChinaCenter for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Department of Respiratory Medicine, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, ChinaBackground: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-analysis, the therapeutic efficiency of terpenoid administration on the lung wet-to-dry weight ratio in rats was investigated.Methods: Using the Cochrane Library, Embase, and PubMed databases, a comprehensive literature search for studies evaluating the therapeutic efficacy of terpenoids on ALI in rats was conducted. The lung wet-to-dry weight ratio was extracted as the main outcome. The quality of the included studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation’s risk of bias tool.Results: In total, 16 studies were included in this meta-analysis. In general, terpenoids significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle (p = 0.0002; standardized mean difference (SMD): −0.16; 95% confidence interval (CI): −0.24, −0.08). Subgroup analysis revealed that low dose (≤10 μmol/kg) (p < 0.0001; SMD: −0.68; 95% CI: −1.02, −0.34), intraperitoneal injection (p = 0.0002; SMD: −0.43; 95% CI: −0.66, −0.20), diterpenoid (p = 0.004; SMD: −0.13; 95% CI: −0.23, −0.04), and triterpenoid (p = 0.04; SMD: −0.28; 95% CI: −0.54, −0.01) significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle.Conclusion: A low dose of diterpenoid and triterpenoid administered intraperitoneally is effective in alleviating ALI. This systematic review and meta-analysis provides a valuable mirror for clinical research aiming at the advancement of terpenoids for preventive and therapeutic use.Systematic Review Registration: CRD42022326779https://www.frontiersin.org/articles/10.3389/fphar.2022.946554/fullacute lung injuryterpenoidslipopolysaccharidelung wet-to-dry weight ratioanimal model |
| spellingShingle | Shuai Wang Sean X. Luo Jing Jie Dan Li Han Liu Lei Song Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies Frontiers in Pharmacology acute lung injury terpenoids lipopolysaccharide lung wet-to-dry weight ratio animal model |
| title | Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies |
| title_full | Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies |
| title_fullStr | Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies |
| title_full_unstemmed | Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies |
| title_short | Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies |
| title_sort | efficacy of terpenoids in attenuating pulmonary edema in acute lung injury a meta analysis of animal studies |
| topic | acute lung injury terpenoids lipopolysaccharide lung wet-to-dry weight ratio animal model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.946554/full |
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