Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance
Heat-stable enterotoxins are the most notable virulence factors associated with Staphylococcus aureus, a common pathogen associated with serious community and hospital acquired diseases. Staphylococcal enterotoxins (SEs) cause toxic shock-like syndromes and have been implicated in food poisoning. Bu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/2/8/2117/ |
| _version_ | 1798024596169949184 |
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| author | Antonio Gálvez Hikmate Abriouel Rosario Lucas Elena Ortega |
| author_facet | Antonio Gálvez Hikmate Abriouel Rosario Lucas Elena Ortega |
| author_sort | Antonio Gálvez |
| collection | DOAJ |
| description | Heat-stable enterotoxins are the most notable virulence factors associated with Staphylococcus aureus, a common pathogen associated with serious community and hospital acquired diseases. Staphylococcal enterotoxins (SEs) cause toxic shock-like syndromes and have been implicated in food poisoning. But SEs also act as superantigens that stimulate T-cell proliferation, and a high correlation between these activities has been detected. Most of the nosocomial S. aureus infections are caused by methicillin-resistant S. aureus (MRSA) strains, and those resistant to quinolones or multiresistant to other antibiotics are emerging, leaving a limited choice for their control. This review focuses on these diverse roles of SE, their possible correlations and the influence in disease progression and therapy. |
| first_indexed | 2024-04-11T18:05:07Z |
| format | Article |
| id | doaj.art-4a6d4c4caad14a73a6b66f459bb2f697 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T18:05:07Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-4a6d4c4caad14a73a6b66f459bb2f6972022-12-22T04:10:20ZengMDPI AGToxins2072-66512010-08-01282117213110.3390/toxins2082117Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic ResistanceAntonio GálvezHikmate AbriouelRosario LucasElena OrtegaHeat-stable enterotoxins are the most notable virulence factors associated with Staphylococcus aureus, a common pathogen associated with serious community and hospital acquired diseases. Staphylococcal enterotoxins (SEs) cause toxic shock-like syndromes and have been implicated in food poisoning. But SEs also act as superantigens that stimulate T-cell proliferation, and a high correlation between these activities has been detected. Most of the nosocomial S. aureus infections are caused by methicillin-resistant S. aureus (MRSA) strains, and those resistant to quinolones or multiresistant to other antibiotics are emerging, leaving a limited choice for their control. This review focuses on these diverse roles of SE, their possible correlations and the influence in disease progression and therapy.http://www.mdpi.com/2072-6651/2/8/2117/enterotoxinsStaphylococcus aureussuperantigensMRSAimmune response |
| spellingShingle | Antonio Gálvez Hikmate Abriouel Rosario Lucas Elena Ortega Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance Toxins enterotoxins Staphylococcus aureus superantigens MRSA immune response |
| title | Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance |
| title_full | Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance |
| title_fullStr | Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance |
| title_full_unstemmed | Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance |
| title_short | Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance |
| title_sort | multiple roles of staphylococcus aureus enterotoxins pathogenicity superantigenic activity and correlation to antibiotic resistance |
| topic | enterotoxins Staphylococcus aureus superantigens MRSA immune response |
| url | http://www.mdpi.com/2072-6651/2/8/2117/ |
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