Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives
Background: The locoregional recurrence of breast cancer has been reduced due to the multidisciplinary approach of breast surgery, systemic therapy and radiation. Early detection and better surgical techniques contribute to an improvement in breast cancer outcomes. Purpose of Review: The purpose of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/8/545 |
| _version_ | 1797585037393133568 |
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| author | Sayeh Lavasani Erin Healy Kari Kansal |
| author_facet | Sayeh Lavasani Erin Healy Kari Kansal |
| author_sort | Sayeh Lavasani |
| collection | DOAJ |
| description | Background: The locoregional recurrence of breast cancer has been reduced due to the multidisciplinary approach of breast surgery, systemic therapy and radiation. Early detection and better surgical techniques contribute to an improvement in breast cancer outcomes. Purpose of Review: The purpose of this review is to have an overview and summary of the current evidence behind the current approaches to the locoregional treatment of breast cancer and to discuss its future direction. Summary: With improved surgical techniques and the use of a more effective neoadjuvant systemic therapy, including checkpoint inhibitors and dual HER2-directed therapies that lead to a higher frequency of pathologic complete responses and advances in adjuvant radiation therapy, breast cancer patients are experiencing better locoregional control and reduced local and systemic recurrence. De-escalation in surgery has not only improved the quality of life in the majority of breast cancer patients, but also maintained the low risk of recurrence. There are ongoing clinical trials to optimize radiation therapy in breast cancer. More modern radiation technologies are evolving to improve the patient outcome and reduce radiation toxicities. |
| first_indexed | 2024-03-11T00:01:11Z |
| format | Article |
| id | doaj.art-4a6d6250003c4ce9b45e88b3b698c4f3 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T00:01:11Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-4a6d6250003c4ce9b45e88b3b698c4f32023-11-19T00:46:39ZengMDPI AGCurrent Oncology1198-00521718-77292023-08-013087520753110.3390/curroncol30080545Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future PerspectivesSayeh Lavasani0Erin Healy1Kari Kansal2Division of Hematology and Medical Oncology, UC Irvine, Orange, CA 92868, USADepartment of Radiation Oncology, UC Irvine, Orange, CA 92868, USADivision of Breast Surgery, UC Irvine, Orange, CA 92868, USABackground: The locoregional recurrence of breast cancer has been reduced due to the multidisciplinary approach of breast surgery, systemic therapy and radiation. Early detection and better surgical techniques contribute to an improvement in breast cancer outcomes. Purpose of Review: The purpose of this review is to have an overview and summary of the current evidence behind the current approaches to the locoregional treatment of breast cancer and to discuss its future direction. Summary: With improved surgical techniques and the use of a more effective neoadjuvant systemic therapy, including checkpoint inhibitors and dual HER2-directed therapies that lead to a higher frequency of pathologic complete responses and advances in adjuvant radiation therapy, breast cancer patients are experiencing better locoregional control and reduced local and systemic recurrence. De-escalation in surgery has not only improved the quality of life in the majority of breast cancer patients, but also maintained the low risk of recurrence. There are ongoing clinical trials to optimize radiation therapy in breast cancer. More modern radiation technologies are evolving to improve the patient outcome and reduce radiation toxicities.https://www.mdpi.com/1718-7729/30/8/545breast cancerlocoregional treatmentde-escalation breast surgery |
| spellingShingle | Sayeh Lavasani Erin Healy Kari Kansal Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives Current Oncology breast cancer locoregional treatment de-escalation breast surgery |
| title | Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives |
| title_full | Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives |
| title_fullStr | Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives |
| title_full_unstemmed | Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives |
| title_short | Locoregional Treatment for Early-Stage Breast Cancer: Current Status and Future Perspectives |
| title_sort | locoregional treatment for early stage breast cancer current status and future perspectives |
| topic | breast cancer locoregional treatment de-escalation breast surgery |
| url | https://www.mdpi.com/1718-7729/30/8/545 |
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