Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery

Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery

AbstractThe purpose of this study was to develop poloxamer (P407)-based in-situ thermogellable hydrogels with reducing concentration of P407 by adding hypromellose (HPMC) and with enhancing mucoadhesion of resulting hydrogels by adding hyaluronic acid (HA) for prolonging ocular delivery of hydroxypr...

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Bibliographic Details
Main Authors: Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu, Hong-Liang Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Drug Delivery
Subjects:
Thermosensitive in situ Hydrogel
Poloxamer 407
HPMC
Hyaluronic acid
Hydroxypropyl β-cyclodextrin
Testosterone
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2158964

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