Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice
Objective(s): Cisplatin (CDDP) is a highly effective chemotherapeutic agent, but its clinical application has been limited by nephrotoxicity. Tanshinone Ⅰ (T-I), a phenanthrenequinone compound extracted from the Chinese herb Danshen, has been used to improve circulation and treat cardiovascular dise...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_19684_a82c570fe439519ce9ca957e32f72d43.pdf |
| _version_ | 1819210448718790656 |
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| author | Yan Wang Yun-hui Zhang Yin-ru Tang Jie Lan Zhi-ying Huang Wei Tian Qian Huang Yan Peng Yuan Gao Yue-qin Hu Xue-nong Zhang |
| author_facet | Yan Wang Yun-hui Zhang Yin-ru Tang Jie Lan Zhi-ying Huang Wei Tian Qian Huang Yan Peng Yuan Gao Yue-qin Hu Xue-nong Zhang |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Objective(s): Cisplatin (CDDP) is a highly effective chemotherapeutic agent, but its clinical application has been limited by nephrotoxicity. Tanshinone Ⅰ (T-I), a phenanthrenequinone compound extracted from the Chinese herb Danshen, has been used to improve circulation and treat cardiovascular diseases. The aim of this study was to investigate the protective effect of T-I on CDDP-induced nephrotoxicity in mice.Materials and Methods: The BALB/c mouse models of nephrotoxicity were established by a single intraperitoneal injection of 20 mg/kg CDDP on the first day of the experiment. Three hours prior to CDDP administration, the mice were dosed with 10 mg/kg and 30 mg/kg T-I for 3 consecutive days intraperitoneally to explore nephroprotection of T-I.Results: Treatment with T-I significantly reduced blood urea nitrogen and creatinine levels in serum observed in CDDP-administered mice, especially at a dose of 30 mg/kg. T-I at 30 mg/kg significantly decreased malondialdehyde levels and increased glutathione levels and the enzymatic activity of catalase in kidney tissue compared to CDDP. Additionally, T-I (30 mg/kg) significantly reversed the CDDP-decreased expression level of superoxide dismutase 2 protein in renal tissue. Histopathological evaluation of the kidneys further confirmed the protective effect of T-I. Conclusion: The findings of this study demonstrate that T-I can protect against CDDP-induced nephrotoxicity through suppression of oxidative stress. |
| first_indexed | 2024-12-23T06:11:21Z |
| format | Article |
| id | doaj.art-4a6ef5b1217c418b9de681913c8cf48e |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-23T06:11:21Z |
| publishDate | 2022-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-4a6ef5b1217c418b9de681913c8cf48e2022-12-21T17:57:26ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-03-0125341441810.22038/ijbms.2022.58959.1310219684Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in miceYan Wang0Yun-hui Zhang1Yin-ru Tang2Jie Lan3Zhi-ying Huang4Wei Tian5Qian Huang6Yan Peng7Yuan Gao8Yue-qin Hu9Xue-nong Zhang10Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. ChinaDepartment of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaDepartment of Nephrology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaDepartment of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaDepartment of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaDepartment of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaDepartment of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, P.R. ChinaObjective(s): Cisplatin (CDDP) is a highly effective chemotherapeutic agent, but its clinical application has been limited by nephrotoxicity. Tanshinone Ⅰ (T-I), a phenanthrenequinone compound extracted from the Chinese herb Danshen, has been used to improve circulation and treat cardiovascular diseases. The aim of this study was to investigate the protective effect of T-I on CDDP-induced nephrotoxicity in mice.Materials and Methods: The BALB/c mouse models of nephrotoxicity were established by a single intraperitoneal injection of 20 mg/kg CDDP on the first day of the experiment. Three hours prior to CDDP administration, the mice were dosed with 10 mg/kg and 30 mg/kg T-I for 3 consecutive days intraperitoneally to explore nephroprotection of T-I.Results: Treatment with T-I significantly reduced blood urea nitrogen and creatinine levels in serum observed in CDDP-administered mice, especially at a dose of 30 mg/kg. T-I at 30 mg/kg significantly decreased malondialdehyde levels and increased glutathione levels and the enzymatic activity of catalase in kidney tissue compared to CDDP. Additionally, T-I (30 mg/kg) significantly reversed the CDDP-decreased expression level of superoxide dismutase 2 protein in renal tissue. Histopathological evaluation of the kidneys further confirmed the protective effect of T-I. Conclusion: The findings of this study demonstrate that T-I can protect against CDDP-induced nephrotoxicity through suppression of oxidative stress.https://ijbms.mums.ac.ir/article_19684_a82c570fe439519ce9ca957e32f72d43.pdfcisplatinmicenephrotoxicityoxidative stresstanshinone ⅰ |
| spellingShingle | Yan Wang Yun-hui Zhang Yin-ru Tang Jie Lan Zhi-ying Huang Wei Tian Qian Huang Yan Peng Yuan Gao Yue-qin Hu Xue-nong Zhang Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice Iranian Journal of Basic Medical Sciences cisplatin mice nephrotoxicity oxidative stress tanshinone ⅰ |
| title | Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice |
| title_full | Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice |
| title_fullStr | Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice |
| title_full_unstemmed | Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice |
| title_short | Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice |
| title_sort | protective effects of tanshinone i against cisplatin induced nephrotoxicity in mice |
| topic | cisplatin mice nephrotoxicity oxidative stress tanshinone ⅰ |
| url | https://ijbms.mums.ac.ir/article_19684_a82c570fe439519ce9ca957e32f72d43.pdf |
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