Functional evolution of SARS-CoV-2 spike protein: Maintaining wide host spectrum and enhancing infectivity via surface charge of spike protein

Functional evolution of SARS-CoV-2 spike protein: Maintaining wide host spectrum and enhancing infectivity via surface charge of spike protein

The SARS-CoV-2 virus, which causes the COVID-19, is rapidly accumulating mutations to adapt to the hosts. We collected SARS-CoV-2 sequence data from the end of 2019 to January 2023 to analyze for their evolutionary features during the pandemic. We found that most of the SARS-CoV-2 genes are undergoi...

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Bibliographic Details
Main Authors: Xiaolong Lu, Yang Chen, Gong Zhang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
Charge adaptation
Codon usage adaptation
Ka/Ks evolution
Spike protein
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702300106X

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