Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent
Abstract Aromatic amines are a large group of chemical compounds that have attracted the attention of researchers due to their toxicity and carcinogenicity. This study aimed to develop an efficient method for sampling and analysis of aromatic amines (Aniline, N, N-dimethylaniline, 2-chloroaniline, a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31108-7 |
| _version_ | 1797864748389236736 |
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| author | Razzagh Rahimpoor Khaled Murtada Ali Firoozichahak Babak Pashaei Danial Soleymani-ghoozhdi Houman Serkan Faeze Mehregan Saber Alizadeh |
| author_facet | Razzagh Rahimpoor Khaled Murtada Ali Firoozichahak Babak Pashaei Danial Soleymani-ghoozhdi Houman Serkan Faeze Mehregan Saber Alizadeh |
| author_sort | Razzagh Rahimpoor |
| collection | DOAJ |
| description | Abstract Aromatic amines are a large group of chemical compounds that have attracted the attention of researchers due to their toxicity and carcinogenicity. This study aimed to develop an efficient method for sampling and analysis of aromatic amines (Aniline, N, N-dimethylaniline, 2-chloroaniline, and 3-chloroaniline) from the vapour phase (headspace) of urine samples. For the implementation of this plan, a needle trap device packed with the three-component adsorbent consisting of nano-Hydroxy Apatite (nHA), Zeolite (Ze), and Metal–Organic Framework (MOF) equipped with GC-FID was employed for the first phase. Examination of the prepared adsorbents was performed by FT-IR, PXRD, and FE-SEM techniques. The optimal value of considerable parameters such as time and temperature of extraction, salt content, and pH were established using the Response Surface Methodology-Central Composite Design (RMS-CCD) method. In this way, the optimal extraction of targeted analytes was accomplished in 41 min at 41 °C with NaCl content of 33.0% (w/v) and pH: 13.0, respectively. Also, the repeatability and reproducibility of the method were calculated to be in the range of 2.2–7.1% and 3.9–8.1%, respectively, which indicates the acceptable precision of the method. Also, the limit of detection (LOD) and limit of quantification (LOQ) were determined in the range of 0.3–32.0 ng.L−1 and 0.8–350.0 ng.L−1, respectively, which proves the high sensitivity of the proposed method. Furthermore, the recovery percent of the extracted analytes was concluded in the range of 97.0–99.0% after 6 and 30 days of the sampling and storage at 25 °C and 4 °C, respectively. Finally, the designed procedure was employed in the analysis of the above-mentioned aromatic amines in the real urine samples. The achieved results illustrate that the three-component absorbent system (nHA;Ze;MOF@NTD) can be introduced as an efficient, fast-response, sensitive, and versatile procedure for trace analysis of the different aromatic amine compounds in public and occupational health. |
| first_indexed | 2024-04-09T22:57:09Z |
| format | Article |
| id | doaj.art-4a728d6a97fc4fc39dee18f3c0ac0a05 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:57:09Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4a728d6a97fc4fc39dee18f3c0ac0a052023-03-22T11:11:31ZengNature PortfolioScientific Reports2045-23222023-03-0113111310.1038/s41598-023-31108-7Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbentRazzagh Rahimpoor0Khaled Murtada1Ali Firoozichahak2Babak Pashaei3Danial Soleymani-ghoozhdi4Houman Serkan5Faeze Mehregan6Saber Alizadeh7Department of Occupational Health Engineering, Research Center for Health Sciences, School of Health, Larestan University of Medical SciencesDepartment of Chemistry, University of WaterlooDepartment of Occupational Health, Faculty of Health, Social Determinants of Health Research Center, Gonabad University of Medical ScienceUniversity of MazandaranFaculty of Public Health, Kerman University of Medical SciencesThe Islamic Azad University, Science and Research BranchSchool of Medicine, Shahrekord University of Medical SciencesDepartment of Chemistry, Bu-Ali-Sina UniversityAbstract Aromatic amines are a large group of chemical compounds that have attracted the attention of researchers due to their toxicity and carcinogenicity. This study aimed to develop an efficient method for sampling and analysis of aromatic amines (Aniline, N, N-dimethylaniline, 2-chloroaniline, and 3-chloroaniline) from the vapour phase (headspace) of urine samples. For the implementation of this plan, a needle trap device packed with the three-component adsorbent consisting of nano-Hydroxy Apatite (nHA), Zeolite (Ze), and Metal–Organic Framework (MOF) equipped with GC-FID was employed for the first phase. Examination of the prepared adsorbents was performed by FT-IR, PXRD, and FE-SEM techniques. The optimal value of considerable parameters such as time and temperature of extraction, salt content, and pH were established using the Response Surface Methodology-Central Composite Design (RMS-CCD) method. In this way, the optimal extraction of targeted analytes was accomplished in 41 min at 41 °C with NaCl content of 33.0% (w/v) and pH: 13.0, respectively. Also, the repeatability and reproducibility of the method were calculated to be in the range of 2.2–7.1% and 3.9–8.1%, respectively, which indicates the acceptable precision of the method. Also, the limit of detection (LOD) and limit of quantification (LOQ) were determined in the range of 0.3–32.0 ng.L−1 and 0.8–350.0 ng.L−1, respectively, which proves the high sensitivity of the proposed method. Furthermore, the recovery percent of the extracted analytes was concluded in the range of 97.0–99.0% after 6 and 30 days of the sampling and storage at 25 °C and 4 °C, respectively. Finally, the designed procedure was employed in the analysis of the above-mentioned aromatic amines in the real urine samples. The achieved results illustrate that the three-component absorbent system (nHA;Ze;MOF@NTD) can be introduced as an efficient, fast-response, sensitive, and versatile procedure for trace analysis of the different aromatic amine compounds in public and occupational health.https://doi.org/10.1038/s41598-023-31108-7 |
| spellingShingle | Razzagh Rahimpoor Khaled Murtada Ali Firoozichahak Babak Pashaei Danial Soleymani-ghoozhdi Houman Serkan Faeze Mehregan Saber Alizadeh Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent Scientific Reports |
| title | Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent |
| title_full | Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent |
| title_fullStr | Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent |
| title_full_unstemmed | Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent |
| title_short | Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent |
| title_sort | urinary bio monitoring of aromatic amine derivatives by new needle trap device packed with the multi component adsorbent |
| url | https://doi.org/10.1038/s41598-023-31108-7 |
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