Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease
Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/1/190 |
| _version_ | 1797495547740815360 |
|---|---|
| author | Yu-Ran Lee Eun Young Bae Hong Ryang Kil Byeong-Hwa Jeon Geena Kim |
| author_facet | Yu-Ran Lee Eun Young Bae Hong Ryang Kil Byeong-Hwa Jeon Geena Kim |
| author_sort | Yu-Ran Lee |
| collection | DOAJ |
| description | Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD. Three groups, including 32 patients with KD (KD group), 33 patients with fever (Fever group), and 19 healthy individuals (Healthy group), were prospectively analyzed. APE1/Ref-1 levels were measured, and the clinical characteristics of KD were evaluated. The mean age of all patients was 2.7 ± 1.8 years, but the Healthy group participants were older than the other participants. Fever duration was longer in the KD group than in the fever group. APE1/Ref-1 levels were significantly higher in the KD group (<i>p</i> = 0.004) than in the other two groups, but there was no difference between the healthy and fever groups. APE1/Ref-1 levels did not differ according to fever duration or coronary arterial lesion but were higher in refractory KD cases than in non-refractory cases. APE1/Ref-1 levels were significantly higher during the acute phase of KD. We propose that APE1/Ref-1 could be a beneficial biological marker for the diagnosis and prognosis of KD, especially in refractory KD. |
| first_indexed | 2024-03-10T01:50:54Z |
| format | Article |
| id | doaj.art-4a72b22ca7284f5aae6dade8e3381429 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T01:50:54Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4a72b22ca7284f5aae6dade8e33814292023-11-23T13:05:19ZengMDPI AGBiomedicines2227-90592022-01-0110119010.3390/biomedicines10010190Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki DiseaseYu-Ran Lee0Eun Young Bae1Hong Ryang Kil2Byeong-Hwa Jeon3Geena Kim4Department of Physiology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaDepartment of Pediatrics, College of Medicine, Chungnam National University Hospital, Chungnam National University, Daejeon 35015, KoreaDepartment of Pediatrics, College of Medicine, Chungnam National University Hospital, Chungnam National University, Daejeon 35015, KoreaDepartment of Physiology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaDepartment of Pediatrics, College of Medicine, Chungnam National University Sejong Hospital, Chungnam National University, Sejong 30099, KoreaKawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and KD. Three groups, including 32 patients with KD (KD group), 33 patients with fever (Fever group), and 19 healthy individuals (Healthy group), were prospectively analyzed. APE1/Ref-1 levels were measured, and the clinical characteristics of KD were evaluated. The mean age of all patients was 2.7 ± 1.8 years, but the Healthy group participants were older than the other participants. Fever duration was longer in the KD group than in the fever group. APE1/Ref-1 levels were significantly higher in the KD group (<i>p</i> = 0.004) than in the other two groups, but there was no difference between the healthy and fever groups. APE1/Ref-1 levels did not differ according to fever duration or coronary arterial lesion but were higher in refractory KD cases than in non-refractory cases. APE1/Ref-1 levels were significantly higher during the acute phase of KD. We propose that APE1/Ref-1 could be a beneficial biological marker for the diagnosis and prognosis of KD, especially in refractory KD.https://www.mdpi.com/2227-9059/10/1/190apurinic/apyrimidinic endonuclease-1/redox factor-1mucocutaneous lymph node syndromevasculitis |
| spellingShingle | Yu-Ran Lee Eun Young Bae Hong Ryang Kil Byeong-Hwa Jeon Geena Kim Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease Biomedicines apurinic/apyrimidinic endonuclease-1/redox factor-1 mucocutaneous lymph node syndrome vasculitis |
| title | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
| title_full | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
| title_fullStr | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
| title_full_unstemmed | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
| title_short | Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease |
| title_sort | elevated plasma apurinic apyrimidinic endonuclease 1 redox effector factor 1 levels in refractory kawasaki disease |
| topic | apurinic/apyrimidinic endonuclease-1/redox factor-1 mucocutaneous lymph node syndrome vasculitis |
| url | https://www.mdpi.com/2227-9059/10/1/190 |
| work_keys_str_mv | AT yuranlee elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT eunyoungbae elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT hongryangkil elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT byeonghwajeon elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease AT geenakim elevatedplasmaapurinicapyrimidinicendonuclease1redoxeffectorfactor1levelsinrefractorykawasakidisease |