APOBEC3B: Future direction of liver cancer research
Liver cancer is one of the most common cancers in the world, and the rate of liver cancer is high due to the of its illness. The main risk factor for liver cancer is infection with the hepatitis B virus (HBV), but a considerable number of genetic and epigenetic factors are also directly or indirectl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.996115/full |
| _version_ | 1798035840247529472 |
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| author | Xingyue Yang Jing Dai Shun Yao Jiaxing An Guorong Wen Hai Jin Li Zhang Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo Biguang Tuo |
| author_facet | Xingyue Yang Jing Dai Shun Yao Jiaxing An Guorong Wen Hai Jin Li Zhang Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo Biguang Tuo |
| author_sort | Xingyue Yang |
| collection | DOAJ |
| description | Liver cancer is one of the most common cancers in the world, and the rate of liver cancer is high due to the of its illness. The main risk factor for liver cancer is infection with the hepatitis B virus (HBV), but a considerable number of genetic and epigenetic factors are also directly or indirectly involved in the underlying pathogenesis of liver cancer. In particular, the apolipoprotein B mRNA editing enzyme, catalytic peptide-like protein (APOBEC) family (DNA or mRNA editor family), which has been the focus of virology research for more than a decade, has been found to play a significant role in the occurrence and development of various cancers, providing a new direction for the research of liver cancer. APOBEC3B is a cytosine deaminase that controls a variety of biological processes, such as protein expression, innate immunity, and embryonic development, by participating in the process of cytidine deamination to uridine in DNA and RNA. In humans, APOBEC3B has long been known as a DNA editor for limiting viral replication and transcription. APOBEC3B is widely expressed at low levels in a variety of normal tissues and organs, but it is significantly upregulated in different types of tumor tissues and tumor lines. Thus, APOBEC3B has received increasing attention in various cancers, but the role of APOBEC3B in the occurrence and development of liver cancer due to infection with HBV remains unclear. This review provides a brief introduction to the pathogenesis of hepatocellular carcinoma induced by HBV, and it further explores the latest results of APOBEC3B research in the development of HBV and liver cancer, thereby providing new directions and strategies for the treatment and prevention of liver cancer. |
| first_indexed | 2024-04-11T21:03:52Z |
| format | Article |
| id | doaj.art-4a730264145341f698a821ccf7e09b3b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T21:03:52Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4a730264145341f698a821ccf7e09b3b2022-12-22T04:03:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.996115996115APOBEC3B: Future direction of liver cancer researchXingyue Yang0Jing Dai1Shun Yao2Jiaxing An3Guorong Wen4Hai Jin5Li Zhang6Liming Zheng7Xingyue Chen8Zhiqiang Yi9Biguang Tuo10Biguang Tuo11Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine of Zunyi Medical University, Zunyi, ChinaLiver cancer is one of the most common cancers in the world, and the rate of liver cancer is high due to the of its illness. The main risk factor for liver cancer is infection with the hepatitis B virus (HBV), but a considerable number of genetic and epigenetic factors are also directly or indirectly involved in the underlying pathogenesis of liver cancer. In particular, the apolipoprotein B mRNA editing enzyme, catalytic peptide-like protein (APOBEC) family (DNA or mRNA editor family), which has been the focus of virology research for more than a decade, has been found to play a significant role in the occurrence and development of various cancers, providing a new direction for the research of liver cancer. APOBEC3B is a cytosine deaminase that controls a variety of biological processes, such as protein expression, innate immunity, and embryonic development, by participating in the process of cytidine deamination to uridine in DNA and RNA. In humans, APOBEC3B has long been known as a DNA editor for limiting viral replication and transcription. APOBEC3B is widely expressed at low levels in a variety of normal tissues and organs, but it is significantly upregulated in different types of tumor tissues and tumor lines. Thus, APOBEC3B has received increasing attention in various cancers, but the role of APOBEC3B in the occurrence and development of liver cancer due to infection with HBV remains unclear. This review provides a brief introduction to the pathogenesis of hepatocellular carcinoma induced by HBV, and it further explores the latest results of APOBEC3B research in the development of HBV and liver cancer, thereby providing new directions and strategies for the treatment and prevention of liver cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.996115/fullliver cancerhbvAPOBEC3BAPOBEC familyNF-κB signaling pathways |
| spellingShingle | Xingyue Yang Jing Dai Shun Yao Jiaxing An Guorong Wen Hai Jin Li Zhang Liming Zheng Xingyue Chen Zhiqiang Yi Biguang Tuo Biguang Tuo APOBEC3B: Future direction of liver cancer research Frontiers in Oncology liver cancer hbv APOBEC3B APOBEC family NF-κB signaling pathways |
| title | APOBEC3B: Future direction of liver cancer research |
| title_full | APOBEC3B: Future direction of liver cancer research |
| title_fullStr | APOBEC3B: Future direction of liver cancer research |
| title_full_unstemmed | APOBEC3B: Future direction of liver cancer research |
| title_short | APOBEC3B: Future direction of liver cancer research |
| title_sort | apobec3b future direction of liver cancer research |
| topic | liver cancer hbv APOBEC3B APOBEC family NF-κB signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.996115/full |
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