Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International

Summary: Objective: To stimulate future research directions that seek solutions for osteoarthritis (OA) at the interface between diverse disciplines and address osteoarthritis (OA) as a serious disease with a complexity that has presented a barrier to finding safe effective solutions. Methods: Sess...

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Main Authors: Thomas P. Andriacchi, Timothy M. Griffin, Richard F. Loeser, Jr., Constance R. Chu, Ewa M. Roos, Gillian A. Hawker, Jennifer C. Erhart-Hledik, Arielle G. Fischer
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913120300108
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author Thomas P. Andriacchi
Timothy M. Griffin
Richard F. Loeser, Jr.
Constance R. Chu
Ewa M. Roos
Gillian A. Hawker
Jennifer C. Erhart-Hledik
Arielle G. Fischer
author_facet Thomas P. Andriacchi
Timothy M. Griffin
Richard F. Loeser, Jr.
Constance R. Chu
Ewa M. Roos
Gillian A. Hawker
Jennifer C. Erhart-Hledik
Arielle G. Fischer
author_sort Thomas P. Andriacchi
collection DOAJ
description Summary: Objective: To stimulate future research directions that seek solutions for osteoarthritis (OA) at the interface between diverse disciplines and address osteoarthritis (OA) as a serious disease with a complexity that has presented a barrier to finding safe effective solutions. Methods: Sessions were conducted at the 2019 meetings of the Orthopaedic Research Society (ORS) and Osteoarthritis Research Society International (OARSI) that included presentations and questions/comments submitted from leading OA researchers representing imaging, mechanics, biomarkers, phenotyping, clinical, epidemiology, inflammation and exercise. Results: Solutions for OA require a paradigm shift in research and clinical methods in which OA is contextualized as a complex whole-body/person disease. New OA definition(s)/phenotype(s) and OA markers/signals are needed to address the interplay between genetic and environmental factors of the disease as well as capture the mechanosensitivity of the disease. The term “Mechanokines” was proposed to highlight the importance of incorporating whole body mechanics as a marker of early OA. New interventions and apparent paradoxical observations/questions (e.g. exercise vs. load modification) were also discussed in the context of considering OA as a complex system. Conclusion: To advance new OA treatments that are safe and effective, OA should be considered as a “Whole Person” disease. This approach requires a concerted effort to bridge disciplines and include interactions across scales from the molecule to the whole body, including psychosocial aspects.
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spelling doaj.art-4a73644692c74f389775fbfdd80748e62022-12-21T22:37:11ZengElsevierOsteoarthritis and Cartilage Open2665-91312020-03-0121100026Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society InternationalThomas P. Andriacchi0Timothy M. Griffin1Richard F. Loeser, Jr.2Constance R. Chu3Ewa M. Roos4Gillian A. Hawker5Jennifer C. Erhart-Hledik6Arielle G. Fischer7Department of Mechanical Engineering, Stanford University, Stanford, CA, USA; Corresponding author. Stanford University, Bldg. 520, Rm 232, Stanford, California, 94305-4040, USA.Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Reynolds Oklahoma Center on Aging, Department of Biochemistry and Molecular Biology, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Veterans Affairs Medical Center, Oklahoma City, OK, USADivision of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, The University of North Carolina, Chapel Hill, NC, USAPalo Alto Veterans Hospital, Palo Alto, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USACentre for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230, Odense, DenmarkDepartment of Medicine, University of Toronto, Toronto, ON, CanadaPalo Alto Veterans Hospital, Palo Alto, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USADepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA; Palo Alto Veterans Hospital, Palo Alto, CA, USASummary: Objective: To stimulate future research directions that seek solutions for osteoarthritis (OA) at the interface between diverse disciplines and address osteoarthritis (OA) as a serious disease with a complexity that has presented a barrier to finding safe effective solutions. Methods: Sessions were conducted at the 2019 meetings of the Orthopaedic Research Society (ORS) and Osteoarthritis Research Society International (OARSI) that included presentations and questions/comments submitted from leading OA researchers representing imaging, mechanics, biomarkers, phenotyping, clinical, epidemiology, inflammation and exercise. Results: Solutions for OA require a paradigm shift in research and clinical methods in which OA is contextualized as a complex whole-body/person disease. New OA definition(s)/phenotype(s) and OA markers/signals are needed to address the interplay between genetic and environmental factors of the disease as well as capture the mechanosensitivity of the disease. The term “Mechanokines” was proposed to highlight the importance of incorporating whole body mechanics as a marker of early OA. New interventions and apparent paradoxical observations/questions (e.g. exercise vs. load modification) were also discussed in the context of considering OA as a complex system. Conclusion: To advance new OA treatments that are safe and effective, OA should be considered as a “Whole Person” disease. This approach requires a concerted effort to bridge disciplines and include interactions across scales from the molecule to the whole body, including psychosocial aspects.http://www.sciencedirect.com/science/article/pii/S2665913120300108OsteoarthritisBiomechanicsBiomarkersImaging
spellingShingle Thomas P. Andriacchi
Timothy M. Griffin
Richard F. Loeser, Jr.
Constance R. Chu
Ewa M. Roos
Gillian A. Hawker
Jennifer C. Erhart-Hledik
Arielle G. Fischer
Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
Osteoarthritis and Cartilage Open
Osteoarthritis
Biomechanics
Biomarkers
Imaging
title Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
title_full Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
title_fullStr Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
title_full_unstemmed Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
title_short Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International
title_sort bridging disciplines as a pathway to finding new solutions for osteoarthritis a collaborative program presented at the 2019 orthopaedic research society and the osteoarthritis research society international
topic Osteoarthritis
Biomechanics
Biomarkers
Imaging
url http://www.sciencedirect.com/science/article/pii/S2665913120300108
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