Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms.
This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed....
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4408111?pdf=render |
| _version_ | 1818581746330894336 |
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| author | Naoyoshi Nagata Kayo Sakamoto Tomohiro Arai Ryota Niikura Takuro Shimbo Masafumi Shinozaki Noriko Ihana Katsunori Sekine Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Mikio Yanase Junichi Akiyama Naomi Uemura Mitsuhiko Noda |
| author_facet | Naoyoshi Nagata Kayo Sakamoto Tomohiro Arai Ryota Niikura Takuro Shimbo Masafumi Shinozaki Noriko Ihana Katsunori Sekine Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Mikio Yanase Junichi Akiyama Naomi Uemura Mitsuhiko Noda |
| author_sort | Naoyoshi Nagata |
| collection | DOAJ |
| description | This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.Some bowel symptom scores were significantly (p<0.05) different between the age groups, sexes, smoking, and alcohol consumption. In multivariate analysis, constipation was associated with low BMI (p<0.01), low VAT area (p = 0.01), and low SAT area (p<0.01). Moreover, hard stools was associated with low BMI (p<0.01) and low SAT area (p<0.01). The remaining symptoms were not significantly associated with BMI or intra-abdominal fat. Test-retest reliability of bowel symptom scores with a mean duration of 7.5 months was good (mean kappa, 0.672).Both low BMI and low abdominal fat accumulation appears to be useful indicators of increased risk for constipation and hard stools. The long-term test-retest reliability of symptom score suggests that bowel symptoms relevant to BMI or visceral fat remain consistent over several months. |
| first_indexed | 2024-12-16T07:38:23Z |
| format | Article |
| id | doaj.art-4a7731f2541b48c3a761b20dcd8b4943 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T07:38:23Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4a7731f2541b48c3a761b20dcd8b49432022-12-21T22:39:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012399310.1371/journal.pone.0123993Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms.Naoyoshi NagataKayo SakamotoTomohiro AraiRyota NiikuraTakuro ShimboMasafumi ShinozakiNoriko IhanaKatsunori SekineHidetaka OkuboKazuhiro WatanabeToshiyuki SakuraiChizu YokoiMikio YanaseJunichi AkiyamaNaomi UemuraMitsuhiko NodaThis study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.Some bowel symptom scores were significantly (p<0.05) different between the age groups, sexes, smoking, and alcohol consumption. In multivariate analysis, constipation was associated with low BMI (p<0.01), low VAT area (p = 0.01), and low SAT area (p<0.01). Moreover, hard stools was associated with low BMI (p<0.01) and low SAT area (p<0.01). The remaining symptoms were not significantly associated with BMI or intra-abdominal fat. Test-retest reliability of bowel symptom scores with a mean duration of 7.5 months was good (mean kappa, 0.672).Both low BMI and low abdominal fat accumulation appears to be useful indicators of increased risk for constipation and hard stools. The long-term test-retest reliability of symptom score suggests that bowel symptoms relevant to BMI or visceral fat remain consistent over several months.http://europepmc.org/articles/PMC4408111?pdf=render |
| spellingShingle | Naoyoshi Nagata Kayo Sakamoto Tomohiro Arai Ryota Niikura Takuro Shimbo Masafumi Shinozaki Noriko Ihana Katsunori Sekine Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Mikio Yanase Junichi Akiyama Naomi Uemura Mitsuhiko Noda Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. PLoS ONE |
| title | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. |
| title_full | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. |
| title_fullStr | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. |
| title_full_unstemmed | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. |
| title_short | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms. |
| title_sort | effect of body mass index and intra abdominal fat measured by computed tomography on the risk of bowel symptoms |
| url | http://europepmc.org/articles/PMC4408111?pdf=render |
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