Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase

Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase

ABSTRACTZoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to humans. Currently, licensed therapeutics...

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Bibliographic Details
Main Authors:	Yu-Lin Yao, Yun Luo, Qi Wang, Rong Geng, Ying Chen, Mei-Qin Liu, Bei Li, Jing Chen, Chun-Guang Wu, Jing-Kun Jia, Jing-Yi Luo, Yan-Tong He, Ting-Ting Jiang, Yan Zhu, Ben Hu, Peng Zhou, Zheng-Li Shi
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Emerging Microbes and Infections
Subjects:	TMEM53 SADS-CoV RdRp activity HKU2-related CoVs coronavirus zoonosis
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2023.2249120

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