Loop competition and extrusion model predicts CTCF interaction specificity
Boundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21368-0 |
| _version_ | 1818858238172463104 |
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| author | Wang Xi Michael A. Beer |
| author_facet | Wang Xi Michael A. Beer |
| author_sort | Wang Xi |
| collection | DOAJ |
| description | Boundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion. |
| first_indexed | 2024-12-19T08:53:06Z |
| format | Article |
| id | doaj.art-4a7e3fcaccb741f6871932d44d8598bb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:53:06Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4a7e3fcaccb741f6871932d44d8598bb2022-12-21T20:28:40ZengNature PortfolioNature Communications2041-17232021-02-0112111510.1038/s41467-021-21368-0Loop competition and extrusion model predicts CTCF interaction specificityWang Xi0Michael A. Beer1Department of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineBoundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.https://doi.org/10.1038/s41467-021-21368-0 |
| spellingShingle | Wang Xi Michael A. Beer Loop competition and extrusion model predicts CTCF interaction specificity Nature Communications |
| title | Loop competition and extrusion model predicts CTCF interaction specificity |
| title_full | Loop competition and extrusion model predicts CTCF interaction specificity |
| title_fullStr | Loop competition and extrusion model predicts CTCF interaction specificity |
| title_full_unstemmed | Loop competition and extrusion model predicts CTCF interaction specificity |
| title_short | Loop competition and extrusion model predicts CTCF interaction specificity |
| title_sort | loop competition and extrusion model predicts ctcf interaction specificity |
| url | https://doi.org/10.1038/s41467-021-21368-0 |
| work_keys_str_mv | AT wangxi loopcompetitionandextrusionmodelpredictsctcfinteractionspecificity AT michaelabeer loopcompetitionandextrusionmodelpredictsctcfinteractionspecificity |