Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism

Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism

Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the host neutrophil to gain access to the nucleus where i...

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Bibliographic Details
Main Authors: Yuri Kim, Jianyang Wang, Emily G. Clemens, Dennis J. Grab, J. Stephen Dumler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Anaplasma phagocytophilum
AnkA
ankyrin repeat proteins
nuclear localization signal
RaDAR
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.828605/full

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