Factors associated with health-related quality of life in people living with HIV in Norway
Abstract Background Despite the advances in the treatment of HIV, people living with HIV (PLHIV) still experience impairment of health-related quality of life (HRQOL). The aim of the study was to explore factors associated with HRQOL in a well-treated Norwegian HIV population. Methods Two hundred an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-023-02098-x |
| _version_ | 1797863456454475776 |
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| author | Vegard Skogen Gudrun E. Rohde Ranveig Langseth Ole Rysstad Tore Sørlie Birgit Lie |
| author_facet | Vegard Skogen Gudrun E. Rohde Ranveig Langseth Ole Rysstad Tore Sørlie Birgit Lie |
| author_sort | Vegard Skogen |
| collection | DOAJ |
| description | Abstract Background Despite the advances in the treatment of HIV, people living with HIV (PLHIV) still experience impairment of health-related quality of life (HRQOL). The aim of the study was to explore factors associated with HRQOL in a well-treated Norwegian HIV population. Methods Two hundred and forty-five patients were recruited from two outpatient clinics to participate in this cross-sectional study of addiction, mental distress, post-traumatic stress disorder, fatigue, somatic health, and HRQOL. The latter was measured using the 36-Item Short Form Health Survey (SF-36). Stepwise multiple linear regression analysis was used to examine the adjusted associations between demographic and disease-related variables and HRQOL. Results The study population was virologically and immunologically stable. Their mean age was 43.8 (SD = 11.7) years, 131 (54%) were men, and 33% were native Norwegians. Compared with the general population (published in previous studies), patients reported worse SF-36 scores for five of eight domains: mental health, general health, social function, physical role limitation, and emotional role limitation (all p < 0.001). Compared with men, women reported better SF-36 scores within the domains vitality (63.1 (23.6) vs. 55.9 (26.7), p = 0.026) and general health (73.4 (23.2) vs. 64.4 (30.1), p = 0.009). In the multivariate analyses, higher SF-36- physical component score values were independently associated with young age (p = 0.020), being employed, student, or pensioner (p = 0.009), low comorbidity score (p = 0.015), low anxiety and depression score (p = 0.015), being at risk of drug abuse (p = 0.037), and not being fatigued (p < 0.001). Higher SF-36-mental component score values were independently associated with older age (p = 0.018), being from a country outside Europe or from Norway (p = 0.029), shorter time since diagnosis, low anxiety and depression score (p < 0.001), answering ‘no’ regarding alcohol abuse (p = 0.013), and not being fatigued (p < 0.001). Conclusions HRQOL was poorer in PLHIV than in the general population in Norway. It is important to focus on somatic and mental comorbidities when delivering health-care services in the ageing population of PLHIV to improve HRQOL even among a well-treated group of PLHIV as found in Norway. |
| first_indexed | 2024-04-09T22:35:54Z |
| format | Article |
| id | doaj.art-4a7f26968e47491196c592d6b7cca4b5 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-04-09T22:35:54Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-4a7f26968e47491196c592d6b7cca4b52023-03-22T12:26:58ZengBMCHealth and Quality of Life Outcomes1477-75252023-02-0121111010.1186/s12955-023-02098-xFactors associated with health-related quality of life in people living with HIV in NorwayVegard Skogen0Gudrun E. Rohde1Ranveig Langseth2Ole Rysstad3Tore Sørlie4Birgit Lie5Department of Infectious Diseases, Division of Internal Medicine, University Hospital of North NorwayDepartment of Clinical Research, Sørlandet HospitalDepartment of Infectious Diseases, Division of Internal Medicine, University Hospital of North NorwayDepartment of Internal Medicine, Sørlandet HospitalDepartment of Clinical Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of NorwayDepartment of Psychosomatic and Trauma, Sørlandet HospitalAbstract Background Despite the advances in the treatment of HIV, people living with HIV (PLHIV) still experience impairment of health-related quality of life (HRQOL). The aim of the study was to explore factors associated with HRQOL in a well-treated Norwegian HIV population. Methods Two hundred and forty-five patients were recruited from two outpatient clinics to participate in this cross-sectional study of addiction, mental distress, post-traumatic stress disorder, fatigue, somatic health, and HRQOL. The latter was measured using the 36-Item Short Form Health Survey (SF-36). Stepwise multiple linear regression analysis was used to examine the adjusted associations between demographic and disease-related variables and HRQOL. Results The study population was virologically and immunologically stable. Their mean age was 43.8 (SD = 11.7) years, 131 (54%) were men, and 33% were native Norwegians. Compared with the general population (published in previous studies), patients reported worse SF-36 scores for five of eight domains: mental health, general health, social function, physical role limitation, and emotional role limitation (all p < 0.001). Compared with men, women reported better SF-36 scores within the domains vitality (63.1 (23.6) vs. 55.9 (26.7), p = 0.026) and general health (73.4 (23.2) vs. 64.4 (30.1), p = 0.009). In the multivariate analyses, higher SF-36- physical component score values were independently associated with young age (p = 0.020), being employed, student, or pensioner (p = 0.009), low comorbidity score (p = 0.015), low anxiety and depression score (p = 0.015), being at risk of drug abuse (p = 0.037), and not being fatigued (p < 0.001). Higher SF-36-mental component score values were independently associated with older age (p = 0.018), being from a country outside Europe or from Norway (p = 0.029), shorter time since diagnosis, low anxiety and depression score (p < 0.001), answering ‘no’ regarding alcohol abuse (p = 0.013), and not being fatigued (p < 0.001). Conclusions HRQOL was poorer in PLHIV than in the general population in Norway. It is important to focus on somatic and mental comorbidities when delivering health-care services in the ageing population of PLHIV to improve HRQOL even among a well-treated group of PLHIV as found in Norway.https://doi.org/10.1186/s12955-023-02098-xHIVHealth-related quality of lifeShort Form 36Mental healthSomatic health |
| spellingShingle | Vegard Skogen Gudrun E. Rohde Ranveig Langseth Ole Rysstad Tore Sørlie Birgit Lie Factors associated with health-related quality of life in people living with HIV in Norway Health and Quality of Life Outcomes HIV Health-related quality of life Short Form 36 Mental health Somatic health |
| title | Factors associated with health-related quality of life in people living with HIV in Norway |
| title_full | Factors associated with health-related quality of life in people living with HIV in Norway |
| title_fullStr | Factors associated with health-related quality of life in people living with HIV in Norway |
| title_full_unstemmed | Factors associated with health-related quality of life in people living with HIV in Norway |
| title_short | Factors associated with health-related quality of life in people living with HIV in Norway |
| title_sort | factors associated with health related quality of life in people living with hiv in norway |
| topic | HIV Health-related quality of life Short Form 36 Mental health Somatic health |
| url | https://doi.org/10.1186/s12955-023-02098-x |
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