UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS
Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2017-12-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/79221 |
| _version_ | 1827582204356591616 |
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| author | Andressa Tassinari da Silva Gabriela Rossi Brabo Isadora Dias Marques Lisiane Bajerski Marcelo Donadel Malesuik Clésio Soldateli Paim |
| author_facet | Andressa Tassinari da Silva Gabriela Rossi Brabo Isadora Dias Marques Lisiane Bajerski Marcelo Donadel Malesuik Clésio Soldateli Paim |
| author_sort | Andressa Tassinari da Silva |
| collection | DOAJ |
| description |
Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solvent. The method was specific, linear, precise, exact and robust at 210 nm, confirming that the method is fast and useful to the routine quality control of bilastine in tablets. The validate method was compared to liquid chromatography (HPLC), which was previously developed and validated to the same drug, and no significative difference between the methods using Student´s t test was found to bilastine quantitation.
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| first_indexed | 2024-03-08T22:48:04Z |
| format | Article |
| id | doaj.art-4a839938c92a464bb8a54825d82f301d |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T22:48:04Z |
| publishDate | 2017-12-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-4a839938c92a464bb8a54825d82f301d2023-12-16T18:14:04ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162017-12-0112UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESSAndressa Tassinari da SilvaGabriela Rossi BraboIsadora Dias MarquesLisiane BajerskiMarcelo Donadel MalesuikClésio Soldateli Paim Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solvent. The method was specific, linear, precise, exact and robust at 210 nm, confirming that the method is fast and useful to the routine quality control of bilastine in tablets. The validate method was compared to liquid chromatography (HPLC), which was previously developed and validated to the same drug, and no significative difference between the methods using Student´s t test was found to bilastine quantitation. https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/79221 |
| spellingShingle | Andressa Tassinari da Silva Gabriela Rossi Brabo Isadora Dias Marques Lisiane Bajerski Marcelo Donadel Malesuik Clésio Soldateli Paim UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS Drug Analytical Research |
| title | UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS |
| title_full | UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS |
| title_fullStr | UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS |
| title_full_unstemmed | UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS |
| title_short | UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS |
| title_sort | uv spectrophotometric method for quantitative determination of bilastine using experimental design for robustness |
| url | https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/79221 |
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